Mir-BHRF1-3 microRNA precursor family


mir-BHRF1-3 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-BHRF1-3
Identifiers
Symbolmir-BHRF1-3
RfamRF00367
Other data
RNA typeGene; miRNA
Domain(s)Viruses
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus).[1] In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[2] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.[2]

BHRF-1-3 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein–Barr virus genome.[3] BHRF-3 has been shown to be expressed in latency-III infected lymphoblasts.[4]

References

  1. ^ Qureshi A, Thakur N, Monga I, Thakur A, Kumar M (1 January 2014). "VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets". Database. 2014: bau103. doi:10.1093/database/bau103. PMC 4224276. PMID 25380780.
  2. ^ a b Pfeffer S, Zavolan M, Grässer FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T (April 2004). "Identification of virus-encoded microRNAs". Science. 304 (5671): 734–6. doi:10.1126/science.1096781. PMID 15118162. S2CID 25287167.
  3. ^ Feederle R, Haar J, Bernhardt K, Linnstaedt SD, Bannert H, Lips H, Cullen BR, Delecluse HJ (October 2011). "The members of an Epstein–Barr virus microRNA cluster cooperate to transform B lymphocytes". Journal of Virology. 85 (19): 9801–10. doi:10.1128/JVI.05100-11. PMC 3196389. PMID 21752900.
  4. ^ Xing L, Kieff E (September 2007). "Epstein–Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication". Journal of Virology. 81 (18): 9967–75. doi:10.1128/JVI.02244-06. PMC 2045418. PMID 17626073.


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