Mir-135 microRNA precursor family

mir-135 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-135
Identifiers
Symbolmir-135
RfamRF00246
miRBaseMI0000452
miRBase familyMIPF0000028
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

The miR-135 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. It has been shown to be expressed in human, mouse and rat.[1][2] miR-135 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000028). Precursor microRNAs are ~70 nucleotides in length and are processed by the Dicer enzyme to produce the shorter 21-24 nucleotide mature sequence. In this case the mature sequence is excised from the 5' arm of the hairpin.

Targets of miR-135

  • Nagel et al.. showed that miR-135a and b target the 3' untranslated region of the APC gene.[3]

References

  1. ^ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. hdl:11858/00-001M-0000-0010-94EF-7. PMID 12007417. S2CID 7901788.
  2. ^ Kim, J; Krichevsky A; Grad Y; Hayes GD; Kosik KS; Church GM; Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci USA. 101 (1): 360–365. Bibcode:2004PNAS..101..360K. doi:10.1073/pnas.2333854100. PMC 314190. PMID 14691248.
  3. ^ Nagel R, le Sage C, Diosdado B, et al. (July 2008). "Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer". Cancer Research. 68 (14): 5795–802. doi:10.1158/0008-5472.CAN-08-0951. PMID 18632633.



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