Mir-633 microRNA precursor family

mir-633
Identifiers
Symbolmir-633
RfamRF01028
miRBase familyMIPF0000546
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-633 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-633 in Leukaemia

miR-633 has been linked to acute lymphoblastic leukaemia (ALL) and as having a potential role in the development of leukaemia, due to abnormal expression in ALL subjects.[1] It may be of use for prediction of relapse potential and in development of personalised leukaemia treatments.

Progesterone regulation

miR-633 expression in endometrial carcinoma cells upon treatment with progesterone saw a 50% decrease in expression levels. These point towards a possible critical role of miR-633, alongside other miRNAs, in the regulation of posttranscriptional gene expression on progesterone treatment.[2]

See also

References

  1. ^ Xu L, Liang YN, Luo XQ, Liu XD, Guo HX (2011). "[Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia]". Zhonghua Xue Ye Xue Za Zhi. 32 (3): 178–81. PMID 21535956.
  2. ^ Bae J, Won M, Kim DY, Kim JH, Kim YM, Kim YT, et al. (2012). "Identification of differentially expressed microRNAs in endometrial cancer cells after progesterone treatment". Int J Gynecol Cancer. 22 (4): 561–5. doi:10.1097/IGC.0b013e31824927db. PMID 22543862. S2CID 205679152.


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