Mir-192/215 microRNA precursor

mir-192/215 microRNA precursor
Predicted secondary structure and sequence conservation of mir-192
Identifiers
Symbolmir-192
RfamRF00130
miRBaseMI0000234
miRBase familyMIPF0000063
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

The miR-192 microRNA precursor (homologous to miR-215), is a short non-coding RNA gene involved in gene regulation. miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and human.[1][2]

microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.[3]

mir-192 and mir-215 are thought to be positive regulators of p53, a human tumour suppressor.[4] They are also overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets.[5] It has also been suggested that mir-192 could be used as a biomarker for drug-induced liver damage.[6]

miR-215 and miR-192 are also both implicated in major depressive disorder. Small-RNA sequencing reveals upregulated expression for both miR-215 and miR-192 in the synaptosomes derived from the dorsolateral prefrontal cortex of MDD subjects.[7]

References

  1. ^ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (Feb 2003). "New microRNAs from mouse and human". RNA. 9 (2): 175–9. doi:10.1261/rna.2146903. PMC 1370382. PMID 12554859.
  2. ^ "miRNA gene family: mir-192". mirBASE. University of Manchester. Archived from the original on September 29, 2007.
  3. ^ Ambros V (Dec 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  4. ^ Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM (Oct 2010). "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development". Cancer Cell. 18 (4): 367–81. doi:10.1016/j.ccr.2010.09.005. PMC 3561766. PMID 20951946. (Retracted, see doi:10.1016/j.ccell.2022.10.006, PMID 36306791,  Retraction Watch. If this is an intentional citation to a retracted paper, please replace {{retracted|...}} with {{retracted|...|intentional=yes}}.)
  5. ^ Jin Z, Selaru FM, Cheng Y, Kan T, Agarwal R, Mori Y, Olaru AV, Yang J, David S, Hamilton JP, Abraham JM, Harmon J, Duncan M, Montgomery EA, Meltzer SJ (Mar 2011). "MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro". Oncogene. 30 (13): 1577–85. doi:10.1038/onc.2010.534. PMC 4586057. PMID 21119604.
  6. ^ Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood LE, Galas DJ (Mar 2009). "Circulating microRNAs, potential biomarkers for drug-induced liver injury". Proceedings of the National Academy of Sciences of the United States of America. 106 (11): 4402–7. doi:10.1073/pnas.0813371106. PMC 2657429. PMID 19246379.
  7. ^ Yoshino Y, Roy B, Dwivedi Y (Apr 2021). "Differential and unique patterns of synaptic miRNA expression in dorsolateral prefrontal cortex of depressed subjects". Neuropsychopharmacology. 46 (5): 900–910. doi:10.1038/s41386-020-00861-y. PMC 8115313. PMID 32919404.