Mir-590 microRNA precursor family

mir-590
Identifiers
Symbolmir-590
RfamRF00928
miRBase familyMIPF0000418
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-590 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Nicotine-induced atrial remodelling

Downregulation of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling. This downregulation sees the removal of post-transcriptional repression of TGF-β1 and TGF-β receptor type II (TGF-βRII), and consequent collagen production.[1] miR-590 downregulation has further been shown to be mediated by activation of alpha-7 nicotinic acetylcholine receptors (α7-nAChRs).

See also

References

  1. ^ Shan H, Zhang Y, Lu Y, Zhang Y, Pan Z, Cai B, Wang N, Li X, Feng T, Hong Y, Yang B (August 2009). "Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovascular Research. 83 (3): 465–72. doi:10.1093/cvr/cvp130. PMID 19398468.

Further reading


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