Mir-671 microRNA precursor family

mir-671
Identifiers
Symbolmir-671
RfamRF00891
miRBase familyMIPF0000358
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-671 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Alcoholic and Non-Alcoholic Fatty Liver Disease

miR-671 expression levels have been found to be vary significantly between the alcoholic and non-alcoholic forms of fatty liver disease.[1]

CDR1 regulation

miR-671 has been seen to negatively regulate the CDR1 (Cerebellar Degeneration-Related protein 1) gene, through the targeting and cleavage of a circular antisense transcript of the CDR1 locus. There is a partnered decrease in CDR1 mRNA levels with this downregulation.[2]

FN1 repression

miR-671 is able to bind to and repress fibronection type 1 (FN1) mRNA at its 3'untranslated region binding site.[3]

See also

References

  1. ^ Estep M, Armistead D, Hossain N, Elarainy H, Goodman Z, Baranova A, et al. (2010). "Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease". Aliment Pharmacol Ther. 32 (3): 487–97. doi:10.1111/j.1365-2036.2010.04366.x. PMID 20497147.
  2. ^ Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ, et al. (2011). "miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA". EMBO J. 30 (21): 4414–22. doi:10.1038/emboj.2011.359. PMC 3230379. PMID 21964070.
  3. ^ Rutnam ZJ, Yang BB (2012). "The non-coding 3' UTR of CD44 induces metastasis by regulating extracellular matrix functions". J Cell Sci. 125 (Pt 8): 2075–85. doi:10.1242/jcs100818. PMID 22637644.

Further reading


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