Mir-370 microRNA precursor family

mir-370
Identifiers
Symbol	mir-370
Rfam	RF00740
miRBase family	MIPF0000167
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-370 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. This microRNA, mir-370-3p, has been shown to play a role in heart failure. The upregulation of mir-370-3p in the sinus node leads to downregulation of the pacemaker ion channel, HCN4, and thus downregulation of the corresponding ionic current, which causes sinus bradycardia.[1]

See also

• MicroRNA

References

1. Yanni, Joseph; D’Souza, Alicia; Wang, Yanwen; Li, Ning; Hansen, Brian J.; Zakharkin, Stanislav O.; Smith, Matthew; Hayward, Christina; Whitson, Bryan A.; Mohler, Peter J.; Janssen, Paul M. L.; Zeef, Leo; Choudhury, Moinuddin; Zi, Min; Cai, Xue; Logantha, Sunil Jit R. J.; Nakao, Shu; Atkinson, Andrew; Petkova, Maria; Doris, Ursula; Ariyaratnam, Jonathan; Cartwright, Elizabeth J.; Griffiths-Jones, Sam; Hart, George; Fedorov, Vadim V.; Oceandy, Delvac; Dobrzynski, Halina; Boyett, Mark R. (9 July 2020). "Silencing miR-370-3p rescues funny current and sinus node function in heart failure". Scientific Reports. 10 (1): 11279. doi:10.1038/s41598-020-67790-0. PMC 7347645. PMID 32647133.

Further reading

• Itoh T, Ando M, Tsukamasa Y, Akao Y (June 2012). "Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370". FEBS Letters. 586 (12): 1693–701. doi:10.1016/j.febslet.2012.04.014. PMID 22587915.
• Gao W, He HW, Wang ZM, Zhao H, Lian XQ, Wang YS, Zhu J, Yan JJ, Zhang DG, Yang ZJ, Wang LS (May 2012). "Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease". Lipids in Health and Disease. 11 (1): 55. doi:10.1186/1476-511X-11-55. PMC 3439335. PMID 22587332.
• Mian C, Pennelli G, Fassan M, Balistreri M, Barollo S, Cavedon E, Galuppini F, Pizzi M, Vianello F, Pelizzo MR, Girelli ME, Rugge M, Opocher G (2012). "MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: Preliminary relationships with RET status and outcome". Thyroid. 22 (9): 890–6. doi:10.1089/thy.2012-0045. PMC 3429275. PMID 22747440.
• Sacco J, Adeli K (June 2012). "MicroRNAs: emerging roles in lipid and lipoprotein metabolism". Current Opinion in Lipidology. 23 (3): 220–5. doi:10.1097/MOL.0b013e3283534c9f. PMID 22488426. S2CID 23814795.
• Liu DZ, Ander BP, Tian Y, Stamova B, Jickling GC, Davis RR, Sharp FR (March 2012). "Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells". Gene. 495 (2): 120–7. doi:10.1016/j.gene.2011.12.041. PMID 22244746.
• Lo SS, Hung PS, Chen JH, Tu HF, Fang WL, Chen CY, Chen WT, Gong NR, Wu CW (January 2012). "Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma". Oncogene. 31 (2): 226–37. doi:10.1038/onc.2011.226. PMID 21666718.
• Yoshino H, Chiyomaru T, Enokida H, Kawakami K, Tatarano S, Nishiyama K, Nohata N, Seki N, Nakagawa M (March 2011). "The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer". British Journal of Cancer. 104 (5): 808–18. doi:10.1038/bjc.2011.23. PMC 3048214. PMID 21304530.
• Fernández-Hernando C, Suárez Y, Rayner KJ, Moore KJ (April 2011). "MicroRNAs in lipid metabolism". Current Opinion in Lipidology. 22 (2): 86–92. doi:10.1097/MOL.0b013e3283428d9d. PMC 3096067. PMID 21178770.
• Castilla MÁ, Moreno-Bueno G, Romero-Pérez L, Van De Vijver K, Biscuola M, López-García MÁ, Prat J, Matías-Guiu X, Cano A, Oliva E, Palacios J (January 2011). "Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma". The Journal of Pathology. 223 (1): 72–80. doi:10.1002/path.2802. PMID 21125666. S2CID 38007588.
• Moore KJ, Rayner KJ, Suárez Y, Fernández-Hernando C (December 2010). "microRNAs and cholesterol metabolism". Trends in Endocrinology and Metabolism. 21 (12): 699–706. doi:10.1016/j.tem.2010.08.008. PMC 2991595. PMID 20880716.
• Hoekstra M, van der Lans CA, Halvorsen B, Gullestad L, Kuiper J, Aukrust P, van Berkel TJ, Biessen EA (April 2010). "The peripheral blood mononuclear cell microRNA signature of coronary artery disease". Biochemical and Biophysical Research Communications. 394 (3): 792–7. doi:10.1016/j.bbrc.2010.03.075. PMID 20230787.
• Iliopoulos D, Drosatos K, Hiyama Y, Goldberg IJ, Zannis VI (June 2010). "MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism". Journal of Lipid Research. 51 (6): 1513–23. doi:10.1194/jlr.M004812. PMC 3035515. PMID 20124555.
• Xu CF, Yu CH, Li YM (December 2009). "Regulation of hepatic microRNA expression in response to ischemic preconditioning following ischemia/reperfusion injury in mice". OMICS. 13 (6): 513–20. doi:10.1089/omi.2009.0035. PMID 19780683.
• Haller F, von Heydebreck A, Zhang JD, Gunawan B, Langer C, Ramadori G, Wiemann S, Sahin O (January 2010). "Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31". The Journal of Pathology. 220 (1): 71–86. doi:10.1002/path.2610. PMID 19768731. S2CID 26480742.
• Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM (February 2009). "MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats". Clinical and Experimental Pharmacology & Physiology. 36 (2): 181–8. doi:10.1111/j.1440-1681.2008.05057.x. PMID 18986336. S2CID 205458045.
• Dixon-McIver A, East P, Mein CA, Cazier JB, Molloy G, Chaplin T, Andrew Lister T, Young BD, Debernardi S (May 2008). Seoighe C (ed.). "Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia". PLOS ONE. 3 (5): e2141. Bibcode:2008PLoSO...3.2141D. doi:10.1371/journal.pone.0002141. PMC 2373886. PMID 18478077.
• Meng F, Wehbe-Janek H, Henson R, Smith H, Patel T (January 2008). "Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes". Oncogene. 27 (3): 378–86. doi:10.1038/sj.onc.1210648. PMID 17621267.

External links

• Page for mir-370 microRNA precursor family at Rfam