Mir-625 microRNA precursor family

mir-625
Identifiers
Symbolmir-625
RfamRF01017
miRBase familyMIPF0000534
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-625 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. Many microRNAs play important roles in cancer development and progression.

mir-625 and gastric cancer

mir-625 has been shown to be down regulated in gastric cancers. This is important, as mir-625 is responsible for the regulation of metastasis in gastric tumour cells, and therefore downregulation of mir-625 results in increased metastasis.[1] mir-625 is thought to act by inhibiting the ILK protein.[1]

References

  1. ^ a b Wang M, Li C, Nie H, Lv X, Qu Y, Yu B, Su L, Li J, Chen X, Ju J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B (July 2012). "Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK". FEBS Letters. 586 (16): 2382–8. doi:10.1016/j.febslet.2012.05.050. PMID 22677169.

Further reading


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