MiR-134

miR-134
Conserved secondary structure of miR-134
Identifiers
Symbolmir-134
Alt. SymbolsMIR134
RfamRF00699
miRBaseMI0000474
miRBase familyMIPF0000112
NCBI Gene406924
HGNC31519
Other data
Domain(s)Mammalia
GO0035195
SO0001244
LocusChr. 14 [1]
PDB structuresPDBe

miR-134 is a family of microRNA precursors found in mammals, including humans.[1] MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.[2] The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134.

miR-134 was one of a number of microRNAs found to be increasingly expressed in schizophrenia.[3]

Functions

miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA.[4][5] In the human brain, SIRT1 is thought to mediate CREB protein through miR-134, giving the microRNA a role in higher brain functions such a memory formation.[6]

miR-134 has also been reported to function in mouse embryonic stem cells as part of a complex network regulating their differentiation.[7]

Applications

miR-134 levels in circulating blood could potentially be used as a peripheral biomarker for bipolar disorder.[8]

References

  1. ^ Landgraf P, Rusu M, Sheridan R, et al. (June 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell. 129 (7): 1401–14. doi:10.1016/j.cell.2007.04.040. PMC 2681231. PMID 17604727.
  2. ^ Ambros V (December 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  3. ^ Santarelli DM, Beveridge NJ, Tooney PA, et al. (January 2011). "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry. 69 (2): 180–7. doi:10.1016/j.biopsych.2010.09.030. hdl:1959.13/934011. PMID 21111402. S2CID 33340677.
  4. ^ Schratt GM, Tuebing F, Nigh EA, et al. (January 2006). "A brain-specific microRNA regulates dendritic spine development". Nature. 439 (7074): 283–9. Bibcode:2006Natur.439..283S. doi:10.1038/nature04367. PMID 16421561. S2CID 2177484.
  5. ^ Tai HC, Schuman EM (February 2006). "MicroRNA: microRNAs reach out into dendrites". Current Biology. 16 (4): R121-3. Bibcode:2006CBio...16.R121T. doi:10.1016/j.cub.2006.02.006. PMID 16488859.
  6. ^ Gao J, Wang WY, Mao YW, et al. (August 2010). "A novel pathway regulates memory and plasticity via SIRT1 and miR-134". Nature. 466 (7310): 1105–9. Bibcode:2010Natur.466.1105G. doi:10.1038/nature09271. PMC 2928875. PMID 20622856.
  7. ^ Tay YM, Tam WL, Ang YS, et al. (January 2008). "MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1". Stem Cells. 26 (1): 17–29. doi:10.1634/stemcells.2007-0295. PMID 17916804.
  8. ^ Rong H, Liu TB, Yang KJ, et al. (January 2011). "MicroRNA-134 plasma levels before and after treatment for bipolar mania". Journal of Psychiatric Research. 45 (1): 92–5. doi:10.1016/j.jpsychires.2010.04.028. PMID 20546789.