Mir-601 microRNA precursor family

mir-601
Identifiers
Symbolmir-601
RfamRF01006
miRBase familyMIPF0000522
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-601 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Molecular pathway regulation

miR-601 has been found to affect a number of different cell signalling pathways, more specifically bringing about downregulation of Fas-induced apoptosis and NF-kappa B signalling. There is additionally upregulation of the actin cytoskeleton and increased negative regulation of translational initiation by miR-601.[1] The importance of NF-kappa B in tumour cell proliferation and enhanced survival means that miR-601 mimics may hold a lot of promise for prevention or treatment of carcinogenesis.

miR-602 has further been linked to the development and progression of gastric cancer, with levels significantly upregulated compared with normal gastric tissue.[2]

See also

References

  1. ^ Ohdaira H, Nakagawa H, Yoshida K (2009). "Profiling of molecular pathways regulated by microRNA 601". Computational Biology and Chemistry. 33 (6): 429–33. doi:10.1016/j.compbiolchem.2009.09.003. PMID 19889580.
  2. ^ Yao Y, Suo AL, Li ZF, Liu LY, Tian T, Ni L, et al. (2009). "MicroRNA profiling of human gastric cancer". Molecular Medicine Reports. 2 (6): 963–70. doi:10.3892/mmr_00000199. PMID 21475928.


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