Vasoactive intestinal peptide receptor

vasoactive intestinal peptide receptor 1
Identifiers
Symbol	VIPR1
Alt. symbols	RDC1, HVR1, VAPC1
NCBI gene	7433
HGNC	12694
OMIM	192321
RefSeq	NM_004624
UniProt	P32241
Other data
Locus	Chr. 3 p22
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vasoactive intestinal peptide receptor 2
Identifiers
Symbol	VIPR2
Alt. symbols	VPAC2
NCBI gene	7434
HGNC	12695
OMIM	601970
RefSeq	NM_003382
UniProt	P41587
Other data
Locus	Chr. 7 q36.3
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adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Identifiers
Symbol	ADCYAP1R1
Alt. symbols	PACAPR
NCBI gene	117
HGNC	242
OMIM	102981
RefSeq	NM_001118
UniProt	P41586
Other data
Locus	Chr. 7 p14
Search for Structures Swiss-model Domains InterPro

There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC₁ and VPAC₂.[1][2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.

VPAC₁ is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.

VPAC₂ is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.[3]

References

1. Laburthe M, Couvineau A, Marie JC (2002). "VPAC receptors for VIP and PACAP". Recept. Channels. 8 (3–4): 137–53. doi:10.3109/10606820213680. PMID 12529932.
2. Laburthe M, Couvineau A (2002). "Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP". Regul. Pept. 108 (2–3): 165–73. doi:10.1016/S0167-0115(02)00099-X. PMID 12220741. S2CID 21588275.
3. "VIP and PACAP receptors". IUPHAR Guide to Pharmacology. The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR).

External links

• "VIP and PACAP Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
• Receptors,+Vasoactive+Intestinal+Peptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)