Pyroglutamylated RFamide peptide receptor

QRFPR
Identifiers
Aliases	QRFPR, AQ27, GPR103, SP9155, pyroglutamylated RFamide peptide receptor
External IDs	OMIM: 606925; MGI: 2677633; HomoloGene: 18865; GeneCards: QRFPR; OMA:QRFPR - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	121,381,059 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	36,276,462 bp
RNA expression pattern
	Top expressed in
	gonad; ; renal cortex; ; left ventricle; ; prefrontal cortex; ; primary visual cortex; ; hypothalamus; ; right auricle; ; apex of heart; ; superior frontal gyrus; ; bone marrow cells;
	Top expressed in
	ventromedial nucleus; ; piriform cortex; ; embryo; ; tail of embryo; ; neural layer of retina; ; lumbar subsegment of spinal cord; ; temporal lobe; ; ventricular zone; ; olfactory bulb; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide Y receptor activity; peptide binding; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	cellular response to hormone stimulus; neuropeptide signaling pathway; signal transduction; response to peptide; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84109
	229214
	ENSG00000186867
	ENSMUSG00000058400
	Q96P65
	P83861
	NM_198179
	NM_198192
	NP_937822
	NP_937835
	Wikidata
View/Edit Human	View/Edit Mouse

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.^[5]^[6]

Function

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.^[5]

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.^[7] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058400 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: GPR103 G protein-coupled receptor 103".
^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
^ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
^ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.