F2RL2

F2RL2
Identifiers
Aliases	F2RL2, PAR-3, PAR3, coagulation factor II thrombin receptor like 2
External IDs	OMIM: 601919; MGI: 1298208; HomoloGene: 36151; GeneCards: F2RL2; OMA:F2RL2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	76,623,413 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	95,839,247 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; retinal pigment epithelium; ; skin of thigh; ; gallbladder; ; islet of Langerhans; ; testicle; ; skin of hip; ; gastric mucosa; ; smooth muscle tissue; ; nipple;
	Top expressed in
	lumbar spinal ganglion; ; right lobe of liver; ; gastrula; ; blood; ; tibiofemoral joint; ; yolk sac; ; granulocyte; ; embryo; ; tail of embryo; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thrombin-activated receptor activity; protein binding; signal transducer activity; phosphatidylinositol phospholipase C activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; apical plasma membrane; membrane; protein-containing complex;
Biological process	platelet activation; hemostasis; thrombin-activated receptor signaling pathway; blood coagulation; response to wounding; signal transduction; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2151
	14064
	ENSG00000164220
	ENSMUSG00000021675
	O00254
	O08675
	NM_004101; NM_001256566
	NM_010170
	NP_001243495; NP_004092
	NP_034300
	Wikidata
View/Edit Human	View/Edit Mouse

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Function

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021675 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2".

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Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2". J. Immunol. 167 (11): 6615–22. doi:10.4049/jimmunol.167.11.6615. PMID 11714832.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin". Biochem. Biophys. Res. Commun. 305 (1): 166–8. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212.
Tanaka N, Morita T, Nezu A, et al. (2003). "Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1)". Life Sci. 73 (3): 301–10. doi:10.1016/S0024-3205(03)00269-8. PMID 12757837.