Latrophilin 2

ADGRL2
Identifiers
Aliases	ADGRL2, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
External IDs	OMIM: 607018; MGI: 2139714; HomoloGene: 22712; GeneCards: ADGRL2; OMA:ADGRL2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 81,306,147 bp[1] End 81,993,932 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H3 Start 148,815,583 bp[2] End 148,990,555 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung ventricular zone left lobe of thyroid gland right lobe of thyroid gland left ovary gastric mucosa lower lobe of lung ganglionic eminence right ovary Top expressed in hand maxillary prominence left lung lobe human fetus mandibular prominence renal corpuscle skin of back stria vascularis umbilical cord ventromedial nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity latrotoxin receptor activity signal transducer activity carbohydrate binding Cellular component integral component of membrane membrane intracellular anatomical structure integral component of plasma membrane neuron projection Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway brain development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23266 99633 Ensembl ENSG00000117114 ENSMUSG00000028184 UniProt O95490 Q8JZZ7 RefSeq (mRNA) NM_001297704 NM_001297705 NM_001297706 NM_012302 NM_001330645 NM_001350698 NM_001350699 NM_001366002 NM_001366003 NM_001366004 NM_001366005 NM_001366006 NM_001366007 NM_001366008 NM_001366009 NM_001393349 NM_001393350 NM_001393351 NM_001393352 NM_001393353 NM_001393354 NM_001081298 RefSeq (protein) NP_001284633 NP_001284634 NP_001284635 NP_001317574 NP_036434 NP_001337627 NP_001337628 NP_001352931 NP_001352932 NP_001352933 NP_001352934 NP_001352935 NP_001352936 NP_001352937 NP_001352938 NP_001074767 NP_001392915 NP_001392916 NP_001392917 NP_001392918 NP_001392919 NP_001392920 NP_001392921 NP_001392922 NP_001392923 NP_001392924 NP_001392925 NP_001392926 NP_001392927 NP_001392928 NP_001392929 NP_001392930 NP_001392931 NP_001392932 NP_001392933 NP_001392934 NP_001392935 NP_001392936 NP_001392937 NP_001392938 NP_001392939 NP_001392940 NP_001392947 NP_001392948 Location (UCSC) Chr 1: 81.31 – 81.99 Mb Chr 3: 148.82 – 148.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.[5][6]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[6]

See also

• Adhesion G protein-coupled receptors

References

1. GRCh38: Ensembl release 89: ENSG00000117114 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028184 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
6. "Entrez Gene: LPHN2 latrophilin 2".

Further reading

• Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
• Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• White GR, Varley JM, Heighway J (Dec 1998). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer". Oncogene. 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
• Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007. PMID 17456239.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.