P2RY14

P2RY14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B6V
Identifiers
Aliases	P2RY14, BPR105, GPR105, P2Y14, purinergic receptor P2Y14
External IDs	OMIM: 610116; MGI: 2155705; HomoloGene: 15769; GeneCards: P2RY14; OMA:P2RY14 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	151,278,542 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	59,061,039 bp
RNA expression pattern
	Top expressed in
	decidua; ; skin of hip; ; endothelial cell; ; synovial joint; ; skin of thigh; ; Achilles tendon; ; endometrium; ; gastric mucosa; ; epithelium of colon; ; visceral pleura;
	Top expressed in
	cervix; ; sciatic nerve; ; spleen; ; mesenteric lymph nodes; ; adrenal gland; ; external carotid artery; ; left lung lobe; ; Paneth cell; ; carotid body; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity; G protein-coupled UDP receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	signal transduction; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9934
	140795
	ENSG00000174944
	ENSMUSG00000036381
	Q15391
	Q9ESG6
	NM_001081455; NM_014879
NM_001008497; NM_001287119; NM_001287120; NM_001287121; NM_001287122;
	NM_001287123; NM_001287124; NM_133200
	NP_001074924; NP_055694
NP_001008497; NP_001274048; NP_001274049; NP_001274050; NP_001274051;
	NP_001274052; NP_001274053; NP_573463
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.^[5]

The product of this gene, P2Y₁₄ belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174944 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036381 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14".

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Lee BC, Cheng T, Adams GB, et al. (2003). "P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrowhematopoietic stem cells". Genes Dev. 17 (13): 1592–1604. doi:10.1101/gad.1071503. PMC 196132. PMID 12842911.
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Moore DJ, Murdock PR, Watson JM, et al. (2004). "GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function". Brain Res. Mol. Brain Res. 118 (1–2): 10–23. doi:10.1016/S0169-328X(03)00330-9. PMID 14559350.

External links

"P2Y Receptors: P2Y₁₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.