DNAH6 (англ. Dynein axonemal heavy chain 6) – білок, який кодується однойменним геном, розташованим у людей на 2-й хромосомі.[3] Довжина поліпептидного ланцюга білка становить 4 158 амінокислот, а молекулярна маса — 475 983[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MTFRATDSEF | | DLTNIEEYAE | | NSALSRLNNI | | KAKQRVSYVT | | STENESDTQI |
LTFRHITKAQ | | EKTRKRQQPI | | KLEPLPVLKV | | YQDHKQPEYI | | HEQNRFQLMT |
AGIIKRPVSI | | AKKSFATSST | | QFLEHQDAVK | | KMQIHRPYVE | | VFSPSPPKLP |
HTGIGKRGLF | | GTRSSAYPKY | | TFHDREEVVK | | ANIRDPLQII | | KIIRENEHLG |
FLYMIPAVPR | | SSIEYDTYNL | | KVVSYENINK | | NDYYTISQRA | | VTHIYNEDIE |
FIEIDRWEQE | | YLYHRELTKI | | PIFSLFRKWK | | AFSVWRKNVR | | SKKITGCQKS |
LQKNLFIVNP | | HLRPALLKIN | | ELCYHLSFMG | | LCYIEKCHTY | | TLQEFKAAQV |
IRLAEVTERL | | GEFRNEAKYV | | VRRACRFALR | | AAGFVPDDCA | | FGPFEDYHKV |
QSSGSFINTP | | HELPTYGDSE | | KMTYTEQASK | | RHYCMRLTCF | | IRLNDYLIEN |
TMHILTVNAV | | NSLLNHLTDK | | LKRTPSADVI | | QKWITEEKPE | | VPDKKGTLMV |
EKQEEDESLI | | PMFLTELMLT | | VQSLLFEPSL | | EDFLDGILGA | | VNHCQNTVLS |
VPNLVPDSYF | | DAFTSPYINN | | KLEGKTCGTG | | PSLAAVFEDD | | KNFHTIISQI |
KETIQAAFES | | ARIYAATFEK | | FQIFFKENES | | LDLQALKLQE | | PDINFFSEQL |
EKYHKQHKDA | | VALRPTRNVG | | LLLIDTRLLR | | EKLIPSPLRC | | LEVLNFMLPR |
QSKKKVDAII | | FEAQDAEYKL | | EFVPTTTTEY | | VHSLLFLDEI | | QERIESLEDE |
GNIVTQMYKL | | MEQYQVPTPP | | EDFAVFATMK | | PSIVAVRNAI | | DKSVGDRESS |
IKQFCVHLGS | | DLEELNNEVN | | EVKLQAQDPQ | | ILDISADQDK | | IRLILNNLQS |
VLADLQKRAF | | QYKSYQKNFK | | VEVSKFEALE | | EVSAELKLKQ | | LLWDSFSEWD |
KLQQEWLKSK | | FDCLDPEVLN | | GQVSKYAKFV | | TQLEKGLPPN | | SVVPQLKYKV |
EKMKEKLPVI | | IDLRNPTLKA | | RHWAAIEQTV | | DATLVDAEIP | | LTLERLSQLH |
VFDFGQEIQD | | ISGQASGEAA | | LEAILKKVED | | SWKTTEFVIL | | PHRDSKDVFI |
LGGTDDIQVL | | LDDSTINVAT | | LASSRYLGPL | | KTRVDEWQKQ | | LALFNQTLEE |
WLTCQRNWLY | | LESIFNAPDI | | QRQLPAEAKM | | FLQVDKSWKE | | IMRKVNRLPN |
ALRAATQPGL | | LETFQNNNAL | | LDQIQKCLEA | | YLESKRVIFP | | RFYFLSNDEL |
LEILAQTRNP | | QAVQPHLRKC | | FDSISKLEFA | | LMPPAEGKIP | | GIDGEPEKVY |
TNDILAMLSP | | EGERVSLGKG | | LKARGNVEEW | | LGKVEEAMFT | | SLRRLCKAAI |
ADYQGKLRTD | | WVVAGHPSQV | | ILTVSQIMWC | | RDLTECLETE | | HSNHIQALKN |
FEKVNFERLN | | ALAAIVQGSL | | PKLHRNILTA | | LITIDVHARD | | IVTELVQSKV |
ETVESFDWQR | | QLRYYWDIDL | | DNCVARMALS | | QYTYGYEYLG | | ACPRLVITPL |
TDRCYLCLMG | | ALQLDLGGAP | | AGPAGTGKTE | | TTKDLAKALA | | IQCVVFNCSD |
GLDYKMMGRF | | FSGLAQSGAW | | CCFDEFNRID | | IEVLSVIAQQ | | LITIRNAKAA |
KLSRFMFEGR | | EIKLVMTCAA | | FITMNPGYAG | | RTELPDNLKA | | LFRPFAMMVP |
NYALIAEVIL | | YSEGFESSKI | | LARKMTQMYK | | LCSEQLSQQD | | HYDFGMRAVK |
SVLVMAGSLK | | RENPDLNEDV | | VLIRALQDSN | | LPKFLTDDAL | | LFSGIISDLF |
PGVQIPEHDY | | GILQSTIVDV | | MNRQNLQPEM | | CMVRKVIQFY | | ETMLVRHGVM |
LVGPTGGGKT | | TVYRILAETL | | GNLQKLGIEN | | SFYQAVKTYV | | LNPKSITMGE |
LYGEVNNLTL | | EWKDGLMALS | | VRAAVNDTSE | | DHKWIISDGP | | VDALWIENMN |
TVLDDNKMLC | | LANSERIKLT | | PQIHMLFEVQ | | DLRVASPATV | | SRCGMVFVDP |
EELKWMPYVK | | TWMKGISKKL | | TEETQEYILN | | LFQRYVDEGL | | HFINKKCSQA |
IPQVDISKVT | | TLCCLLESLI | | LGKDGVNLAM | | EQTKLNTILC | | QTFVFCYLWS |
LGGNLTENYY | | DSFDTFIRTQ | | FDDNPDARLP | | NSGDLWSIHM | | DFDTKRLDPW |
ERIIPTFKYN | | RDVPFFEMLV | | PTTDTVRYGY | | LMEKLLAVKH | | SVLFTGITGV |
GKSVIAKGLL | | NKIQESAGYV | | PVYLNFSAQT | | SSARTQEIIE | | SKLERKRKNI |
LGAPGNKRIV | | IFVDDLNMPR | | LDRYGSQPPI | | ELLRQYQDFG | | GFYDRNKLFW |
KEIQDVTIIS | | ACAPPGGGRN | | PVTPRFIRHF | | SMLCLPMPSE | | HSLKQIFQAI |
LNGFLSDFPP | | AVKQTASSIV | | EASVEIYNKM | | SVDLLPTPAK | | SHYVFNLRDL |
SKCVQGILQC | | DPGTIREEIQ | | IFRLFCHECQ | | RVFHDRLINN | | EDKHYFHVIL |
TEMANKHFGI | | AIDLEYFLNK | | PIIFGDFIKF | | GADKADRIYD | | DMPDIEKTAN |
VLQDYLDDYN | | LTNPKEVKLV | | FFQDAIEHVS | | RIARMIRQER | | GNALLVGVGG |
TGKQSLTRLA | | AHICGYKCLQ | | IELSRGYNYD | | SFHEDLRKLY | | KMAGVEDKNM |
VFLFTDTQIV | | VEEFLEDINN | | ILNSGEVPNL | | FEKDELEQVL | | AATRPRAKEV |
GISEGNRDEV | | FQYFISKVRQ | | KLHIVLCMSP | | VGEAFRSRCR | | MFPSLVNCCT |
IDWFVQWPRE | | ALLSVSKTFF | | SQVDAGNEEL | | KEKLPLMCVN | | VHLSVSSMAE |
RYYNELRRRY | | YTTPTSYLEL | | INLYLSMLSE | | KRKQIISARD | | RVKNGLTKLL |
ETNILVDKMK | | LDLSALEPVL | | LAKSEDVEAL | | MEKLAVDQES | | ADQVRNTVQE |
DEATAKVKAE | | ETQAIADDAQ | | RDLDEALPAL | | DAANKALDSL | | DKADISEIRV |
FTKPPDLVMT | | VMEAISILLN | | AKPDWPSAKQ | | LLGDSNFLKR | | LLEYDKENIK |
PQILAKLQKY | | INNPDFVPEK | | VEKVSKACKS | | MCMWVRAMDL | | YSRVVKVVEP |
KRQKLRAAQA | | ELDITMATLR | | EKQALLRQVE | | DQIQALQDEY | | DKGVNEKESL |
AKTMALTKAR | | LVRAGKLTAA | | LEDEQVRWEE | | SIQKFEEEIS | | NITGNVFIAA |
ACVAYYGAFT | | AQYRQSLIEC | | WIQDCQSLEI | | PIDPSFSLIN | | ILGDPYEIRQ |
WNTDGLPRDL | | ISTENGILVT | | QGRRWPLMID | | PQDQANRWIR | | NKESKSGLKI |
IKLTDSNFLR | | ILENSIRLGL | | PVLLEELKET | | LDPALEPILL | | KQIFISGGRL |
LIRLGDSDID | | YDKNFRFYMT | | TKMPNPHYLP | | EVCIKVTIIN | | FTVTKSGLED |
QLLSDVVRLE | | KPRLEEQRIK | | LIVRINTDKN | | QLKTIEEKIL | | RMLFTSEGNI |
LDNEELIDTL | | QDSKITSGAI | | KTRLEEAEST | | EQMINVAREK | | YRPVATQGSV |
MYFVIASLSE | | IDPMYQYSLK | | YFKQLFNTTI | | ETSVKTENLQ | | QRLDVLLEQT |
LLTAYVNVSR | | GLFEQHKLIY | | SFMLCVEMMR | | QQGTLSDAEW | | NFFLRGSAGL |
EKERPPKPEA | | PWLPTATWFA | | CCDLEESFPV | | FHGLTQNILS | | HPISIRLGSF |
ETYINPQKWE | | GYSKMKHEDK | | HMRQEKEAAH | | QDPWSAGLSS | | FHKLILIKCC |
KEEKVVFALT | | DFVIENLGKQ | | FIETPPVDLP | | TLYQDMSCNT | | PLVFILSTGS |
DPMGAFQRFA | | RESGYSERVQ | | SISLGQGQGP | | IAEKMVKDAM | | KSGNWVFLQN |
CHLAVSWMLA | | MEELIKTFTD | | PDSAIKDTFR | | LFLSSMPSNT | | FPVTVLQNSV |
KVTNEPPKGL | | RANIRRAFTE | | MTPSFFEENI | | LGKKWRQIIF | | GICFFHAIIQ |
ERKKFGPLGW | | NICYEFNDSD | | RECALLNLKL | | YCKEGKIPWD | | ALIYITGEIT |
YGGRVTDSWD | | QRCLRTILKR | | FFSPETLEED | | YKYSESGIYF | | APMADSLQEF |
KDYIENLPLI | | DDPEIFGMHE | | NANLVFQYKE | | TSTLINTILE | | VQPRSSTGGE |
GKSNDEIVQE | | LVASVQTRVP | | EKLEMEGASE | | SLFVKDLQGR | | LNSLTTVLGQ |
EVDRFNNLLK | | LIHTSLETLN | | KAIAGFVVMS | | EEMEKVYNSF | | LNNQVPALWS |
NTAYPSLKPL | | GSWVKDLILR | | TSFVDLWLKR | | GQPKSYWISG | | FFFPQGFLTG |
TLQNHARKYN | | LPIDELSFKY | | SVIPTYRDQA | | AVIEAAKTVQ | | FGQELPMDME |
LPSPEDGVLV | | HGMFMDASRW | | DDKEMVIEDA | | LPGQMNPVLP | | VVHFEPQQNY |
KPSPTLYHCP | | LYKTGARAGT | | LSTTGHSTNF | | VVTVLLPSKR | | SKDYWIAKGS |
ALLCQLSE |
Кодований геном білок за функцією належить до білкових моторів.
Задіяний у такому біологічному процесі, як альтернативний сплайсинг.
Білок має сайт для зв'язування з АТФ, нуклеотидами.
Локалізований у цитоплазмі, цитоскелеті, клітинних відростках, війках.
Література
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Примітки
Див. також