PFN2

PFN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D1J
Identifiers
Aliases	PFN2, D3S1319E, PFL, profilin 2
External IDs	OMIM: 176590; MGI: 97550; HomoloGene: 1974; GeneCards: PFN2; OMA:PFN2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	150,050,788 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; superior frontal gyrus; ; postcentral gyrus; ; Brodmann area 10; ; pons; ; middle temporal gyrus; ; orbitofrontal cortex; ; ganglionic eminence; ; glutes; ; ventricular zone;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; phosphatidylinositol-4,5-bisphosphate binding; actin monomer binding; protein binding; ATPase activity;
Cellular component	cytoplasm; terminal bouton; extracellular exosome; cytoskeleton; Schaffer collateral - CA1 synapse; presynapse; postsynapse; glutamatergic synapse;
Biological process	regulation of actin filament polymerization; regulation of synaptic vesicle exocytosis; protein stabilization; positive regulation of actin filament bundle assembly; positive regulation of actin filament polymerization; negative regulation of actin filament polymerization; positive regulation of ATP-dependent activity; negative regulation of epithelial cell migration; positive regulation of stress fiber assembly; actin cytoskeleton organization; positive regulation of peptidyl-serine phosphorylation; negative regulation of ruffle assembly; modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologs
	5217
	18645
	ENSG00000070087
	ENSMUSG00000027805
	P35080
	Q9JJV2
	NM_053024; NM_002628
	NM_019410
	NP_002619; NP_444252
	NP_062283
	Wikidata
View/Edit Human	View/Edit Mouse

Profilin-2 is a protein that in humans is encoded by the PFN2 gene.^[4]^[5]^[6]

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.^[6]

Interactions

PFN2 has been shown to interact with ROCK1,^[7] Vasodilator-stimulated phosphoprotein,^[8]^[9] CCDC113^[10] and FMNL1.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070087 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Joensuu T, Blanco G, Pakarinen L, Sistonen P, Kaariainen H, Brown S, Chapelle A, Sankila EM (March 1997). "Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region". Genomics. 38 (3): 255–63. doi:10.1006/geno.1996.0626. PMID 8975700.
^ Honore B, Madsen P, Andersen AH, Leffers H (October 1993). "Cloning and expression of a novel human profilin variant, profilin II". FEBS Lett. 330 (2): 151–5. doi:10.1016/0014-5793(93)80262-S. PMID 8365484. S2CID 46347046.
^ ^a ^b "Entrez Gene: PFN2 profilin 2".
^ Da Silva JS, Medina Miguel, Zuliani Cecilia, Di Nardo Alessia, Witke Walter, Dotti Carlos G (September 2003). "RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability". J. Cell Biol. 162 (7). United States: 1267–79. doi:10.1083/jcb.200304021. ISSN 0021-9525. PMC 2173969. PMID 14517206.
^ Reinhard M, Giehl K, Abel K, Haffner C, Jarchau T, Hoppe V, Jockusch B M, Walter U (April 1995). "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins". EMBO J. 14 (8). ENGLAND: 1583–9. doi:10.1002/j.1460-2075.1995.tb07146.x. ISSN 0261-4189. PMC 398250. PMID 7737110.
^ Harbeck B, Hüttelmaier S, Schluter K, Jockusch B M, Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. 275 (40). UNITED STATES: 30817–25. doi:10.1074/jbc.M005066200. ISSN 0021-9258. PMID 10882740.
^ "Coiled-Coil Domain Containing 113". GeneCards. Retrieved May 8, 2013.
^ Yayoshi-Yamamoto S, Taniuchi I, Watanabe T (September 2000). "FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages". Mol. Cell. Biol. 20 (18). UNITED STATES: 6872–81. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683.

External links

Overview of all the structural information available in the PDB for UniProt: P35080 (Human Profilin-2) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q9JJV2 (Mouse Profilin-2) at the PDBe-KB.