MYH13

MYH13
Identifiers
Aliases	MYH13, MyHC-IIL, MyHC-eo, myosin, heavy chain 13, skeletal muscle, myosin heavy chain 13
External IDs	OMIM: 603487; MGI: 1339967; HomoloGene: 55780; GeneCards: MYH13; OMA:MYH13 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 10,300,865 bp[1] End 10,373,130 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 40.85 cM Start 67,212,484 bp[2] End 67,262,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad skeletal muscle tissue tibialis anterior muscle muscle of thigh body of stomach synovial joint placenta gastrocnemius muscle fundus myometrium Top expressed in morula skeletal muscle tissue muscle of thigh quadriceps femoris muscle zone of skin blastocyst lung pancreas tail of embryo esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding actin binding microfilament motor activity cytoskeletal motor activity ATP binding calmodulin binding actin filament binding Cellular component cytoplasm myosin filament muscle myosin complex myofibril extracellular exosome myosin complex Biological process muscle contraction cellular response to starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8735 544791 Ensembl ENSG00000006788 ENSMUSG00000060180 UniProt Q9UKX3 n/a RefSeq (mRNA) NM_003802 NM_001081250 RefSeq (protein) NP_003793 n/a Location (UCSC) Chr 17: 10.3 – 10.37 Mb Chr 11: 67.21 – 67.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.[5] [6]

Function

MYH13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000006788 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060180 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Winters LM, Briggs MM, Schachat F (November 1998). "The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17". Genomics. 54 (1): 188–9. doi:10.1006/geno.1998.5558. PMID 9806854.
6. Weiss A, Schiaffino S, Leinwand LA (July 1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.

Further reading

• Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. Bibcode:1999PNAS...96.2958W. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
• Schachat F, Briggs MM (2002). "Phylogenetic implications of the superfast myosin in extraocular muscles". J. Exp. Biol. 205 (Pt 15): 2189–201. doi:10.1242/jeb.205.15.2189. PMID 12110653.
• Trynka G, Zhernakova A, Romanos J, et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Schjeide BM, McQueen MB, Mullin K, et al. (2009). "Assessment of Alzheimer's disease case-control associations using family-based methods". Neurogenetics. 10 (1): 19–25. doi:10.1007/s10048-008-0151-3. PMC 2841132. PMID 18830724.
• Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMC 1886840. PMID 8424456.