KIF7

KIF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XT3, 4A14
Identifiers
Aliases	KIF7, ACLS, HLS2, JBTS12, UNQ340, AGBK, kinesin family member 7
External IDs	OMIM: 611254; MGI: 1098239; HomoloGene: 72555; GeneCards: KIF7; OMA:KIF7 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 89,608,789 bp[1] End 89,655,467 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D2 Start 79,347,846 bp[2] End 79,365,468 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ascending aorta right ovary ventricular zone gastric mucosa stromal cell of endometrium left ovary Descending thoracic aorta left uterine tube testicle Top expressed in hand molar foot ventricular zone maxillary prominence endocardial cushion mandibular prominence medullary collecting duct Gonadal ridge genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding microtubule motor activity nucleotide binding protein binding ATP binding plus-end-directed microtubule motor activity ATPase activity Cellular component cell projection ciliary tip cilium kinesin complex ciliary basal body cytoplasm cytoskeleton microtubule Biological process microtubule-based movement negative regulation of smoothened signaling pathway positive regulation of smoothened signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 374654 16576 Ensembl ENSG00000166813 ENSMUSG00000050382 UniProt Q2M1P5 B7ZNG0 RefSeq (mRNA) NM_198525 NM_001291222 NM_010626 RefSeq (protein) NP_940927 n/a Location (UCSC) Chr 15: 89.61 – 89.66 Mb Chr 7: 79.35 – 79.37 Mb PubMed search [3] [4]
Wikidata
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Kinesin family member 7 (KIF7), also known as kinesin-4, is a human protein encoded by the gene KIF7. It is part of the kinesin family of motor proteins.

Function

KIF7 depolymerises the growing plus-end of microtubules, and is involved in regulating Hedgehog signalling.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000166813 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050382 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV (July 2014). "The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment". Nature Cell Biology. 16 (7): 663–672. doi:10.1038/ncb2988. PMC 4085576. PMID 24952464.