MYH15

MYH15
Identifiers
Aliases	MYH15, myosin heavy chain 15
External IDs	OMIM: 609929; MGI: 3643515; HomoloGene: 18929; GeneCards: MYH15; OMA:MYH15 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.13 Start 108,380,368 bp[1] End 108,529,322 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 48,877,849 bp[2] End 49,019,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum frontal pole middle frontal gyrus gonad testicle optic nerve C1 segment rectum prefrontal cortex cingulate gyrus Top expressed in spermatid secondary oocyte testicle primary oocyte zygote lens dentate gyrus of hippocampal formation granule cell Hypothalamus striatum of neuraxis hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding actin binding cytoskeletal motor activity ATP binding calmodulin binding actin filament binding microtubule motor activity microtubule binding Cellular component cytoplasm myosin filament myofibril myosin complex Biological process extraocular skeletal muscle development microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22989 667772 Ensembl ENSG00000144821 ENSMUSG00000092009 UniProt Q9Y2K3 E9Q264 RefSeq (mRNA) NM_014981 NM_001166210 RefSeq (protein) NP_055796 NP_001159682 Location (UCSC) Chr 3: 108.38 – 108.53 Mb Chr 16: 48.88 – 49.02 Mb PubMed search [3] [4]
Wikidata
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Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.[5]

Function

MYH15 is a slow-twitch myosin.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144821 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000092009 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.

Further reading

• Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
• Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles". J. Physiol. 588 (Pt 2): 353–64. doi:10.1113/jphysiol.2009.181008. PMC 2821527. PMID 19948655.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Stedman HH, Kozyak BW, Nelson A, et al. (2004). "Myosin gene mutation correlates with anatomical changes in the human lineage". Nature. 428 (6981): 415–8. Bibcode:2004Natur.428..415S. doi:10.1038/nature02358. PMID 15042088. S2CID 4304466.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. Biol. Evol. 21 (6): 1042–56. doi:10.1093/molbev/msh103. PMID 15014174.
• Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
• Bare LA, Morrison AC, Rowland CM, et al. (2007). "Five common gene variants identify elevated genetic risk for coronary heart disease". Genet. Med. 9 (10): 682–9. doi:10.1097/GIM.0b013e318156fb62. PMID 18073581.