DYNLL1

DYNLL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CMI, 3ZKE, 3ZKF, 1F95, 1F3C, 1F96
Identifiers
Aliases	DYNLL1, DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1, dynein light chain LC8-type 1
External IDs	OMIM: 601562; MGI: 1861457; HomoloGene: 133063; GeneCards: DYNLL1; OMA:DYNLL1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,498,493 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,439,058 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; frontal pole; ; gingival epithelium; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; bronchial epithelial cell; ; right testis; ; Brodmann area 10; ; right frontal lobe;
	Top expressed in
	medial ganglionic eminence; ; endocardial cushion; ; dentate gyrus of hippocampal formation granule cell; ; maxillary prominence; ; condyle; ; mandibular prominence; ; spermatid; ; hair follicle; ; seminiferous tubule; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein C-terminus binding; protein binding; cytoskeletal motor activity; cytoskeletal protein binding; plus-end-directed microtubule motor activity; dynein intermediate chain binding; dynein light intermediate chain binding; enzyme binding; nitric-oxide synthase regulator activity; protein homodimerization activity; protein heterodimerization activity; scaffold protein binding;
Cellular component	cytoplasm; cytosol; centrosome; membrane; plasma membrane; microtubule associated complex; ciliary tip; mitochondrion; dynein complex; COP9 signalosome; mitotic spindle; microtubule; cytoskeleton; extracellular exosome; nucleus; kinetochore; cytoplasmic dynein complex; cilium; tertiary granule membrane; ficolin-1-rich granule membrane; microtubule organizing center; secretory granule; axon cytoplasm;
Biological process	regulation of transcription, DNA-templated; substantia nigra development; antigen processing and presentation of exogenous peptide antigen via MHC class II; transcription, DNA-templated; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; G2/M transition of mitotic cell cycle; microtubule-based process; intraciliary retrograde transport; viral process; negative regulation of phosphorylation; macroautophagy; apoptotic process; intraciliary transport involved in cilium assembly; neutrophil degranulation; motile cilium assembly; ciliary basal body-plasma membrane docking; positive regulation of non-motile cilium assembly; transport along microtubule; cilium assembly; sister chromatid cohesion; regulation of G2/M transition of mitotic cell cycle; transport; spermatid development; positive regulation of insulin secretion involved in cellular response to glucose stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8655
	56455
	ENSG00000088986
	ENSMUSG00000009013
	P63167
	P63168
	NM_003746; NM_001037494; NM_001037495
	NM_019682
	NP_001032583; NP_001032584; NP_003737
	NP_062656
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene.^[5]^[6]^[7]^[8]

Function

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.^[8]