MAP1B

MAP1B
Identifiers
Aliases	MAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B, PVNH9, DFNA83
External IDs	OMIM: 157129; MGI: 1306778; HomoloGene: 38111; GeneCards: MAP1B; OMA:MAP1B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	72,209,565 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	99,653,048 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; pars compacta; ; middle temporal gyrus; ; pars reticulata; ; Brodmann area 23; ; superior vestibular nucleus; ; pons; ; external globus pallidus; ; parietal lobe; ; postcentral gyrus;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; median eminence; ; substantia nigra; ; medial dorsal nucleus; ; habenula; ; medial vestibular nucleus; ; Rostral migratory stream; ; pontine nuclei; ; medial geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; structural molecule activity; protein binding; actin binding; tubulin binding; phospholipid binding; protein-containing complex binding;
Cellular component	cell projection; postsynaptic density; plasma membrane; dendritic spine; photoreceptor outer segment; synapse; microtubule associated complex; cell junction; microtubule; cytoskeleton; cytoplasm; cytosol; axon; dendrite; somatodendritic compartment; neuronal cell body; apical dendrite; basal dendrite; hippocampal mossy fiber; growth cone; varicosity; perikaryon; perinuclear region of cytoplasm;
Biological process	negative regulation of intracellular transport; axonogenesis; dendrite development; nervous system development; microtubule bundle formation; axon extension; positive regulation of axon extension; mitochondrion transport along microtubule; establishment of monopolar cell polarity; cellular process; microtubule cytoskeleton organization; neuron migration; regulation of microtubule depolymerization; negative regulation of microtubule depolymerization; synapse assembly; response to wounding; response to mechanical stimulus; response to carbohydrate; response to inorganic substance; peripheral nervous system axon regeneration; response to insecticide; developmental maturation; positive regulation of microtubule polymerization; response to nutrient levels; response to estradiol; response to vitamin A; positive regulation of neuron differentiation; neuron development; response to axon injury; induction of synaptic plasticity by chemical substance; cellular response to growth factor stimulus; cellular response to peptide hormone stimulus;
	Sources:Amigo / QuickGO
Orthologs
	4131
	17755
	ENSG00000131711
	ENSMUSG00000052727
	P46821
	P14873
	NM_005909; NM_032010; NM_001324255
	NM_008634
	NP_001311184; NP_005900
	NP_032660
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.^[5]^[6]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.^[6]