ADGRG4 (англ. Adhesion G protein-coupled receptor G4) – білок, який кодується однойменним геном, розташованим у людей на X-хромосомі.[3] Довжина поліпептидного ланцюга білка становить 3 080 амінокислот, а молекулярна маса — 333 368[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MKEHIIYQKL | | YGLILMSSFI | | FLSDTLSLKG | | KKLDFFGRGD | | TYVSLIDTIP |
ELSRFTACID | | LVFMDDNSRY | | WMAFSYITNN | | ALLGREDIDL | | GLAGDHQQLI |
LYRLGKTFSI | | RHHLASFQWH | | TICLIWDGVK | | GKLELFLNKE | | RILEVTDQPH |
NLTPHGTLFL | | GHFLKNESSE | | VKSMMRSFPG | | SLYYFQLWDH | | ILENEEFMKC |
LDGNIVSWEE | | DVWLVNKIIP | | TVDRTLRCFV | | PENMTIQEKS | | TTVSQQIDMT |
TPSQITGVKP | | QNTAHSSTLL | | SQSIPIFATD | | YTTISYSNTT | | SPPLETMTAQ |
KILKTLVDET | | ATFAVDVLST | | SSAISLPTQS | | ISIDNTTNSM | | KKTKSPSSES |
TKTTKMVEAM | | ATEIFQPPTP | | SNFLSTSRFT | | KNSVVSTTSA | | IKSQSAVTKT |
TSLFSTIEST | | SMSTTPCLKQ | | KSTNTGALPI | | STAGQEFIES | | TAAGTVPWFT |
VEKTSPASTH | | VGTASSFPPE | | PVLISTAAPV | | DSVFPRNQTA | | FPLATTDMKI |
AFTVHSLTLP | | TRLIETTPAP | | RTAETELTST | | NFQDVSLPRV | | EDAMSTSMSK |
ETSSKTFSFL | | TSFSFTGTES | | VQTVIDAEAT | | RTALTPEITL | | ASTVAETMLS |
STITGRVYTQ | | NTPTADGHLL | | TLMSTRSAST | | SKAPESGPTS | | TTDEAAHLFS |
SNETIWTSRP | | DQALLASMNT | | TTILTFVPNE | | NFTSAFHENT | | TYTEYLSATT |
NITPLKASPE | | GKGTTANDAT | | TARYTTAVSK | | LTSPWFANFS | | IVSGTTSITN |
MPEFKLTTLL | | LKTIPMSTKP | | ANELPLTPRE | | TVVPSVDIIS | | TLACIQPNFS |
TEESASETTQ | | TEINGAIVFG | | GTTTPVPKSA | | TTQRLNATVT | | RKEATSHYLM |
RKSTIAAVAE | | VSPFSTMLEV | | TDESAQRVTA | | SVTVSSFPDI | | EKLSTPLDNK |
TATTEVRESW | | LLTKLVKTTP | | RSSYNEMTEM | | FNFNHTYVAH | | WTSETSEGIS |
AGSPTSGSTH | | IFGEPLGAST | | TRISETSFST | | TPTDRTATSL | | SDGILPPQPT |
AAHSSATPVP | | VTHMFSLPVN | | GSSVVAEETE | | VTMSEPSTLA | | RAFSTSVLSD |
VSNLSSTTMT | | TALVPPLDQT | | ASTTIVIVPT | | HGDLIRTTSE | | ATVISVRKTS |
MAVPSLTETP | | FHSLRLSTPV | | TAKAETTLFS | | TSVDTVTPST | | HTLVCSKPPP |
DNIPPASSTH | | VISTTSTPEA | | TQPISQVEET | | STYALSFPYT | | FSGGGVVASL |
ATGTTETSVV | | DETTPSHISA | | NKLTTSVNSH | | ISSSATYRVH | | TPVSIQLVTS |
TSVLSSDKDQ | | MTISLGKTPR | | TMEVTEMSPS | | KNSFISYSRG | | TPSLEMTDTG |
FPETTKISSH | | QTHSPSEIPL | | GTPSDGNLAS | | SPTSGSTQIT | | PTLTSSNTVG |
VHIPEMSTSL | | GKTALPSQAL | | TITTFLCPEK | | ESTSALPAYT | | PRTVEMIVNS |
TYVTHSVSYG | | QDTSFVDTTT | | SSSTRISNPM | | DINTTFSHLH | | SLRTQPEVTS |
VASFISESTQ | | TFPESLSLST | | AGLYNDGFTV | | LSDRITTAFS | | VPNVPTMLPR |
ESSMATSTPI | | YQMSSLPVNV | | TAFTSKKVSD | | TPPIVITKSS | | KTMHPGCLKS |
PCTATSGPMS | | EMSSIPVNNS | | AFTPATVSSD | | TSTRVGLFST | | LLSSVTPRTT |
MTMQTSTLDV | | TPVIYAGATS | | KNKMVSSAFT | | TEMIEAPSRI | | TPTTFLSPTE |
PTLPFVKTVP | | TTIMAGIVTP | | FVGTTAFSPL | | SSKSTGAISS | | IPKTTFSPFL |
SATQQSSQAD | | EATTLGILSG | | ITNRSLSTVN | | SGTGVALTDT | | YSRITVPENM |
LSPTHADSLH | | TSFNIQVSPS | | LTSFKSASGP | | TKNVKTTTNC | | FSSNTRKMTS |
LLEKTSLTNY | | ATSLNTPVSY | | PPWTPSSATL | | PSLTSFVYSP | | HSTEAEISTP |
KTSPPPTSQM | | VEFPVLGTRM | | TSSNTQPLLM | | TSWNIPTAEG | | SQFPISTTIN |
VPTSNEMETE | | TLHLVPGPLS | | TFTASQTGLV | | SKDVMAMSSI | | PMSGILPNHG |
LSENPSLSTS | | LRAITSTLAD | | VKHTFEKMTT | | SVTPGTTLPS | | ILSGATSGSV |
ISKSPILTWL | | LSSLPSGSPP | | ATVSNAPHVM | | TSSTVEVSKS | | TFLTSDMISA |
HPFTNLTTLP | | SATMSTILTR | | TIPTPTLGGI | | TTGFPTSLPM | | SINVTDDIVY |
ISTHPEASSR | | TTITANPRTV | | SHPSSFSRKT | | MSPSTTDHTL | | SVGAMPLPSS |
TITSSWNRIP | | TASSPSTLII | | PKPTLDSLLN | | IMTTTSTVPG | | ASFPLISTGV |
TYPFTATVSS | | PISSFFETTW | | LDSTPSFLST | | EASTSPTATK | | STVSFYNVEM |
SFSVFVEEPR | | IPITSVINEF | | TENSLNSIFQ | | NSEFSLATLE | | TQIKSRDISE |
EEMVMDRAIL | | EQREGQEMAT | | ISYVPYSCVC | | QVIIKASSSL | | ASSELMRKIK |
SKIHGNFTHG | | NFTQDQLTLL | | VNCEHVAVKK | | LEPGNCKADE | | TASKYKGTYK |
WLLTNPTETA | | QTRCIKNEDG | | NATRFCSISI | | NTGKSQWEKP | | KFKQCKLLQE |
LPDKIVDLAN | | ITISDENAED | | VAEHILNLIN | | ESPALGKEET | | KIIVSKISDI |
SQCDEISMNL | | THVMLQIINV | | VLEKQNNSAS | | DLHEISNEIL | | RIIERTGHKM |
EFSGQIANLT | | VAGLALAVLR | | GDHTFDGMAF | | SIHSYEEGTD | | PEIFLGNVPV |
GGILASIYLP | | KSLTERIPLS | | NLQTILFNFF | | GQTSLFKTKN | | VTKALTTYVV |
SASISDDMFI | | QNLADPVVIT | | LQHIGGNQNY | | GQVHCAFWDF | | ENNNGLGGWN |
SSGCKVKETN | | VNYTICQCDH | | LTHFGVLMDL | | SRSTVDSVNE | | QILALITYTG |
CGISSIFLGV | | AVVTYIAFHK | | LRKDYPAKIL | | INLCTALLML | | NLVFLINSWL |
SSFQKVGVCI | | TAAVALHYFL | | LVSFTWMGLE | | AVHMYLALVK | | VFNIYIPNYI |
LKFCLVGWGI | | PAIMVAITVS | | VKKDLYGTLS | | PTTPFCWIKD | | DSIFYISVVA |
YFCLIFLMNL | | SMFCTVLVQL | | NSVKSQIQKT | | RRKMILHDLK | | GTMSLTFLLG |
LTWGFAFFAW | | GPMRNFFLYL | | FAIFNTLQGF | | FIFVFHCVMK | | ESVREQWQIH |
LCCGWLRLDN | | SSDGSSRCQI | | KVGYKQEGLK | | KIFEHKLLTP | | SLKSTATSST |
FKSLGSAQGT | | PSEISFPNDD | | FDKDPYCSSP |
Кодований геном білок за функціями належить до рецепторів, g-білокспряжених рецепторів, білків внутрішньоклітинного сигналінгу.
Задіяний у такому біологічному процесі, як альтернативний сплайсинг.
Локалізований у мембрані.
Література
- Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B. (2002). Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett. 531: 407—414. PMID 12435584 DOI:10.1016/S0014-5793(02)03574-3
Примітки
Див. також