ABSTRACTHyaluronic acid is a major macromolecule component of the intercellular matrix of most connective tissues such as joint fluid, vitreous, cord etc. This acid can also be obtained from microorganisms, e.g. the Streptococcus bacteria. As a continuation of a prior research conducted on small scale, the objective of the research was to produce hyaluronic acid from Streptococcus zooepidemicus on a medium scale fermentor (10 L) and to observe the possibility to reduce the utilization of Na2HPO4.2H2O if compared to formerly conducted research (28 g/L). From the three concentrations observed, the natrium phosphate salt consumption of 14 g/L was more favorable financially. Production of hyaluronic acid on a medium scale involved batch and fed-batch wise cultivation at an optimum process condition. Results revealed that fed-batch cultivation increased the yield of hyaluronic acid up to 72 % if compared to batch cultivation with better hyaluronic acid pureness, i.e. 55 %. A significant impact induced by both cultivations were its cultivation time wherein that duration of fed-batch was longer than batch cultivation, consequently producing higher cell and biomass concentrations.Key words: hyaluronic acid, batch/ fed-batch cultivation
| Published by | Institut Pertanian Bogor |
| Journal Name | Jurnal Teknologi Industri Pertanian |
| Contact Phone | - |
| Contact Name | - |
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| Location | Kota bogor, Jawa barat INDONESIA |
| Website | jurnaltin| http://journal.ipb.ac.id/index.php/jurnaltin| |
| ISSN | ISSN : 02163160, EISSN : 22523901, DOI : 10.24961/j.tek.ind.pert, |
| Core Subject | Agriculture, Engineering, |
| Meta Subject | Agriculture, Biological Sciences & Forestry, Engineering, Industrial & Manufacturing Engineering, |
| Meta Desc | The development of science and technology in agriculture, has been instrumental in increasing the production of various agricultural commodities. But climate change is also uncertain world led to decreased agricultural productivity. World energy crisis resulted in higher prices of agricultural commodities due to competition between food and energy are higher. Efforts to utilize biomass (agricultural products) has started a lot of research, not only as raw material for bioenergy, but also in an attempt to exploit agro-products into valuable economic products, and realize clean production in agro-industry. |
| Penulis | TIN, Erliza Noor Dept. |
| Publisher Article | Department of Agroindustrial Technology, Bogor Agricultural University |
| Subtitle Article | Jurnal Teknologi Industri Pertanian Vol. 16 No. 1 (2006): Jurnal Teknologi Industri Pertanian |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | http://journal.ipb.ac.id/index… |
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| Download Article [1] | http://journal.ipb.ac.id/index.php/jurna… |
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Informasi yang terkait dengan PRODUKSI ASAM HIALURONAT OLEH Streptococcus zooepidemicus DENGAN KULTIVASI CURAH (BATCH) DAN SEMI SINAMBUNG (FED BATCH) PADA FERMENTOR SKALA MENENGAH (10 L)
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