Aprikoksib

Aprikoksib
Nama sistematis (IUPAC)
4-[2-(4-Ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]benzenesulfonamide
Data klinis
Kat. kehamilan ?
Status hukum ?
Pengenal
Nomor CAS 162011-90-7
Kode ATC ?
PubChem CID 9820073
ChemSpider 7995822
UNII 5X5HB3VZ3Z
KEGG D08657
Data kimia
Rumus C19H20N2O3S 
SMILES eMolecules & PubChem

  • InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23)
    Key:JTMITOKKUMVWRT-UHFFFAOYSA-N

Aprikoksib merupakan obat antikanker eksperimental. Aprikoksib digolongkan sebagai inhibitor COX-2 yang digunakan untuk meningkatkan respon pengobatan pada penyakit kanker pankreas.[1] Pengembangan aprikoksib dihentikan pada tahun 2015 dikarenakan hasil uji klinik yang cukup buruk.[2]

Referensi

  1. ^ Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, et al. (September 2012). "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer". Clinical Cancer Research. 18 (18): 5031–42. doi:10.1158/1078-0432.CCR-12-0453. PMC 3777527 alt=Dapat diakses gratis. PMID 22829202. 
  2. ^ "Apricoxib". Adis Insight. Springer Nature Switzerland AG. 

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