pt Receptor canabinoide tipo 1

CNR1
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	1LVQ, 1LVR, 2B0Y, 2KOE, 2MZ3, 2MZ2, 2MZA,%%s1LVQ, 1LVR, 2B0Y, 2KOE
Identificadores
Nomes alternativos	CNR1
IDs externos	OMIM: 114610 HomoloGene: 7273 GeneCards: CNR1
Targeted by Drug
	HU-210, win 55212-2, Anandamida, canabinol, Tetraidrocanabinol, Org27569, LY-320135, rimonabanto, TM-38837
Ontologia genética
Função molecular	• G protein-coupled receptor activity; • signal transducer activity; • cannabinoid receptor activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;
Componente celular	• integral component of membrane; • intracellular membrane-bounded organelle; • membrane; • growth cone; • integral component of plasma membrane; • axónio; • membrane raft; • membrana plasmática; • presynaptic membrane; • mitocôndria; • mitochondrial outer membrane; • cell projection; • integral component of mitochondrial membrane; • presynapse; • glutamatergic synapse; • GABA-ergic synapse; • integral component of presynaptic membrane;
Processo biológico	• negative regulation of nitric-oxide synthase activity; • negative regulation of mast cell activation; • glucose homeostasis; • response to nutrient; • regulation of insulin secretion; • negative regulation of blood pressure; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • maternal process involved in female pregnancy; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • response to nicotine; • GO:0010260 envelhecimento; • positive regulation of fever generation; • memória; • negative regulation of action potential; • regulation of feeding behavior; • negative regulation of ion transport; • response to morphine; • negative regulation of fatty acid beta-oxidation; • response to lipopolysaccharide; • positive regulation of blood pressure; • regulation of penile erection; • regulation of lipid metabolic process; • espermatogênese; • positive regulation of neuron projection development; • positive regulation of apoptotic process; • positive regulation of acute inflammatory response to antigenic stimulus; • learning or memory; • nocicepção; • negative regulation of dopamine secretion; • regulation of synaptic transmission, glutamatergic; • response to ethanol; • axonal fasciculation; • regulation of synaptic transmission, GABAergic; • GO:0072468 transdução de sinal; • response to cocaine; • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission; • G protein-coupled receptor signaling pathway; • cannabinoid signaling pathway; • retrograde trans-synaptic signaling by endocannabinoid; • positive regulation of presynaptic cytosolic calcium concentration; • induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	1268
	n/a
	ENSG00000118432
	n/a
	P21554
	n/a
NM_001160226; NM_001160258; NM_001160259; NM_001160260; NM_016083;
	NM_033181; NM_001365869; NM_001365870; NM_001365872; NM_001365874; NM_001370545; NM_001370546; NM_001370547
	n/a
NP_001153698; NP_001153730; NP_001153731; NP_057167; NP_149421;
	NP_001352798; NP_001352799; NP_001352801; NP_001352803; NP_001357474; NP_001357475; NP_001357476
	n/a
	Wikidata
Ver/Editar Humano

O receptor endocanabinoide tipo 1, muitas vezes abreviado para CB1, é um tipo de receptor canabinoide localizado no cérebro. Ele é ativado por neurotransmissores endocanabinoides incluindo a anandamida, a serotonina e a melatonina,etc... e pelo composto psicoativo"THC", encontrado nas flores da planta da cannabis.

Estrutura e Localização

Os receptores CB1 são proteínas acopladas a G (GPCRs) que, quando ativadas, iniciam uma cascata de sinalização intracelular que afeta a neurotransmissão. Eles são codificados pelo gene CNR1 e sua ativação é mediada principalmente pelo ∆9-tetrahidrocanabinol (THC), o principal composto psicoativo encontrado na Cannabis, bem como por endocanabinoides, que são canabinoides produzidos naturalmente pelo corpo, como a anandamida e o 2-aracdonilglicerol (2-AG).

Referências

Este artigo sobre Biologia molecular é um esboço. Você pode ajudar a Wikipédia expandindo-o.

[1] «Drogas que interagem fisicamente com cannabinoid receptor 1 ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

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