Receptor metabotrópico de glutamato 7
O receptor metabotrópico de glutamato 7 é uma proteína que em seres humanos é codificada pelo gene GRM7.[1][2][3][4] Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G.
Interações
O receptor metabotrópico de glutamato 7 mostrou interação com a proteína quinase C 1 (PICK1 [en]).[5]
Referências
- ↑ Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp. «Metabotropic glutamate receptors as novel targets for anxiety and stress disorders» (em inglês). fevereiro de 2005. Consultado em 1 de julho de 2010
- ↑ Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (1994). «Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction». J Biol Chem. 269 (2): 1231–6. PMID 8288585
- ↑ Makoff A, Pilling C, Harrington K, Emson P (1997). «Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS». Brain Res Mol Brain Res. 40 (1): 165–70. PMID 8840028. doi:10.1016/0169-328X(96)00110-6
- ↑ «Entrez Gene: GRM7 glutamate receptor, metabotropic 7»
- ↑ Dev, K K; Nakajima Y, Kitano J, Braithwaite S P, Henley J M, Nakanishi S (2000). «PICK1 interacts with and regulates PKC phosphorylation of mGLUR7». UNITED STATES. J. Neurosci. 20 (19): 7252–7. PMID 11007882
Bibliografia
- Scherer SW, Duvoisin RM, Kuhn R; et al. (1997). «Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.». Genomics. 31 (2): 230–3. PMID 8824806. doi:10.1006/geno.1996.0036
- Flor PJ, Van Der Putten H, Rüegg D; et al. (1997). «A novel splice variant of a metabotropic glutamate receptor, human mGluR7b.». Neuropharmacology. 36 (2): 153–9. PMID 9144652. doi:10.1016/S0028-3908(96)00176-1
- Wu S, Wright RA, Rockey PK; et al. (1998). «Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.». Brain Res. Mol. Brain Res. 53 (1-2): 88–97. PMID 9473604. doi:10.1016/S0169-328X(97)00277-5
- Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S (1999). «A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7.». J. Biol. Chem. 274 (39): 27573–7. PMID 10488094. doi:10.1074/jbc.274.39.27573
- O'Connor V, El Far O, Bofill-Cardona E; et al. (1999). «Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling.». Science. 286 (5442): 1180–4. PMID 10550060. doi:10.1126/science.286.5442.1180
- Barbon A, Ferraboli S, Barlati S (2000). «Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping.». Cytogenet. Cell Genet. 88 (3-4). 288 páginas. PMID 10828612. doi:10.1159/000015541
- Dev KK, Nakajima Y, Kitano J; et al. (2001). «PICK1 interacts with and regulates PKC phosphorylation of mGLUR7.». J. Neurosci. 20 (19): 7252–7. PMID 11007882
- Bolonna AA, Kerwin RW, Munro J; et al. (2001). «Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia.». Schizophr. Res. 47 (1): 99–103. PMID 11163549. doi:10.1016/S0920-9964(99)00235-2
- Hirbec H, Perestenko O, Nishimune A; et al. (2002). «The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.». J. Biol. Chem. 277 (18): 15221–4. PMID 11891216. doi:10.1074/jbc.C200112200
- Enz R (2002). «The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.». FEBS Lett. 514 (2-3): 184–8. PMID 11943148. doi:10.1016/S0014-5793(02)02361-X
- Saugstad JA, Yang S, Pohl J; et al. (2002). «Interaction between metabotropic glutamate receptor 7 and alpha tubulin.». J. Neurochem. 80 (6): 980–8. PMID 11953448. doi:10.1046/j.0022-3042.2002.00778.x
- Schulz HL, Stohr H, Weber BH (2002). «Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7).». Neurosci. Lett. 326 (1): 37–40. PMID 12052533. doi:10.1016/S0304-3940(02)00306-3
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
- Kobayashi Y, Akiyoshi J, Kanehisa M; et al. (2007). «Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.». Psychiatr. Genet. 17 (1). 9 páginas. PMID 17167337. doi:10.1097/YPG.0b013e32801118bc
Ligações externas
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Classe A: Tipo rodopsina | Neurotransmissor | Adrenérgico | |
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Purinérgico | Adenosina ( A1, A2A, A2B, A3) · P2Y ( 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14) |
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Serotonina | (todos, exceto 5-HT3) 5-HT1 ( A, B, D, E, F) · 5-HT2 ( A, B, C) · 5-HT ( 4, 5A, 6, 7) |
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Outros | Acetilcolina ( M1, M2, M3, M4, M5) · Dopamina ( D1, D2, D3, D4, D5) · Histamina ( H1, H2, H3, H4) · Melatonina ( 1A, 1B, 1C) · TAAR ( 1, 2, 3, 5, 6, 8, 9) |
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Metabólitos e moléculas de sinalização | Eicosanoide | CysLT ( 1, 2) · LTB4 ( 1, 2) · FPRL ( 1, 2, 3) · OXE · Prostaglandina ( DP ( 1, 2), EP ( 1, 2, 3, 4), FP) · Prostaciclina · Tromboxano |
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Outros | Ácido biliar · Ácido graxo livre ( 1, 2, 3, 4) · Ácido hidroxicarboxilíco ( 1, 2, 3) · Ácido lisofosfatídico ( 1, 2, 3, 4, 5, 6) · Canabinoide ( CB1, CB2, GPR ( 18, 55, 119)) · EBI2 · Estrogênio · Lisofosfolipídeo ( 1, 2, 3) · Oxoglutarato · PAF · Esfingosina-1-fosfato ( 1, 2, 3, 4, 5) · Succinato |
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Peptídeos | Neuropeptídeo | |
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Outros | Anafilatoxina ( C3a, C5a) · Angiotensina ( 1, 2) · Apelina · Bombesina ( BRS3, GRPR, NMBR) · Bradicinina ( B1, B2) · Quimiocina · Colecistoquinina ( A, B) · Endotelina ( A, B) · Formil peptídeo ( 1, 2, 3) · FSH · Galanina ( 1, 2, 3) · Receptor GHB · Hormônio liberador de gonadotrofina ( 1, 2) · Ghrelina · Kisspeptina · Hormônio luteinizante/coriogonadotropina · MAS ( 1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortina ( 1, 2, 3, 4, 5) · MCHR ( 1, 2) · Motilina · Opioide ( δ, κ, μ, Nociceptina & ζ, mas não σ) · Orexina ( 1, 2) · Oxitocina · Procineticina ( 1, 2) · Peptídeo liberador de prolactina · Relaxina ( 1, 2, 3, 4) · Somatostatina ( 1, 2, 3, 4, 5) · Taquicinina ( 1, 2, 3) · Tirotrofina · Hormônio liberador de tirotropina · Urotensina-II · Vasopressina ( 1A, 1B, 2) |
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Miscelânea | Órfão | GPR ( 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183) |
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Outros | Olfatório · Opsina ( 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Ativado por protease ( 1, 2, 3, 4) · SREB ( 1, 2, 3) |
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Classe B: Tipo secretina | Órfãos | GPR ( 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157) |
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Outros | ADCYAP1R1 · Caderina ( 1, 2, 3) · Calcitonina · CALCRL · CD97 · EMR ( 1, 2, 3) · Glucagon ( GR, GIPR, GLP1R, GLP2R) · Hormônio liberador de corticotrofina ( 1, 2) · Hormônio liberador do hormônio do crescimento · Hormônio paratireoide ( 1, 2) · GPR · Inibidor de angiogênese específico do cérebro ( 1, 2, 3) · Latrofilina ( 1, 2, 3, ELTD1 · Peptídeo intestinal vasoativo ( 1, 2) · Proteínas tipo-Matusalém · Secretina |
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Classe C: Metabotrópico glutamato / feromona | Sabor | TAS1R ( 1, 2, 3) · TAS2R ( 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50) |
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Outros | Sensor de cálcio · GABA B ( 1, 2) · Glutamato ( Metabotrópico de glutamato ( 1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR ( 156, 158, 179) · RAIG ( 1, 2, 3, 4) |
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Class F: Frizzled / Smoothened | |
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