No campo da biologia molecular, P2RY14 é uma proteína que pertence ao grupo dos receptores P2Y e que, em seres humanos, é codificada pelo gene P2RY14.[1]
Referências
Leitura de apoio
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- Abbracchio MP, Boeynaems JM, Barnard EA; et al. (2003). «Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.». Trends Pharmacol. Sci. 24 (2): 52–5. PMID 12559763. doi:10.1016/S0165-6147(02)00038-X
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- Brunschweiger A, Müller CE (2006). «P2 receptors activated by uracil nucleotides--an update.». Curr. Med. Chem. 13 (3): 289–312. PMID 16475938. doi:10.2174/092986706775476052
- Nomura N, Miyajima N, Sazuka T; et al. (1995). «Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.». DNA Res. 1 (1): 27–35. PMID 7584026. doi:10.1093/dnares/1.1.27
- Nomura N, Miyajima N, Sazuka T; et al. (1995). «Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).». DNA Res. 1 (1): 47–56. PMID 7584028. doi:10.1093/dnares/1.1.47
- Charlton ME, Williams AS, Fogliano M; et al. (1997). «The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge.». Brain Res. 764 (1-2): 141–8. PMID 9295203. doi:10.1016/S0006-8993(97)00438-1
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- Wittenberger T, Schaller HC, Hellebrand S (2001). «An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.». J. Mol. Biol. 307 (3): 799–813. PMID 11273702. doi:10.1006/jmbi.2001.4520
- Joensuu T, Hämäläinen R, Yuan B; et al. (2001). «Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.». Am. J. Hum. Genet. 69 (4): 673–84. PMID 11524702. doi:10.1086/323610
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899
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- Moore DJ, Murdock PR, Watson JM; et al. (2004). «GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.». Brain Res. Mol. Brain Res. 118 (1-2): 10–23. PMID 14559350. doi:10.1016/S0169-328X(03)00330-9
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Classe A: Tipo rodopsina | Neurotransmissor | Adrenérgico | |
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Purinérgico | Adenosina ( A1, A2A, A2B, A3) · P2Y ( 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14) |
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Serotonina | (todos, exceto 5-HT3) 5-HT1 ( A, B, D, E, F) · 5-HT2 ( A, B, C) · 5-HT ( 4, 5A, 6, 7) |
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Outros | Acetilcolina ( M1, M2, M3, M4, M5) · Dopamina ( D1, D2, D3, D4, D5) · Histamina ( H1, H2, H3, H4) · Melatonina ( 1A, 1B, 1C) · TAAR ( 1, 2, 3, 5, 6, 8, 9) |
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Metabólitos e moléculas de sinalização | Eicosanoide | CysLT ( 1, 2) · LTB4 ( 1, 2) · FPRL ( 1, 2, 3) · OXE · Prostaglandina ( DP ( 1, 2), EP ( 1, 2, 3, 4), FP) · Prostaciclina · Tromboxano |
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Outros | Ácido biliar · Ácido graxo livre ( 1, 2, 3, 4) · Ácido hidroxicarboxilíco ( 1, 2, 3) · Ácido lisofosfatídico ( 1, 2, 3, 4, 5, 6) · Canabinoide ( CB1, CB2, GPR ( 18, 55, 119)) · EBI2 · Estrogênio · Lisofosfolipídeo ( 1, 2, 3) · Oxoglutarato · PAF · Esfingosina-1-fosfato ( 1, 2, 3, 4, 5) · Succinato |
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Peptídeos | Neuropeptídeo | |
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Outros | Anafilatoxina ( C3a, C5a) · Angiotensina ( 1, 2) · Apelina · Bombesina ( BRS3, GRPR, NMBR) · Bradicinina ( B1, B2) · Quimiocina · Colecistoquinina ( A, B) · Endotelina ( A, B) · Formil peptídeo ( 1, 2, 3) · FSH · Galanina ( 1, 2, 3) · Receptor GHB · Hormônio liberador de gonadotrofina ( 1, 2) · Ghrelina · Kisspeptina · Hormônio luteinizante/coriogonadotropina · MAS ( 1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortina ( 1, 2, 3, 4, 5) · MCHR ( 1, 2) · Motilina · Opioide ( δ, κ, μ, Nociceptina & ζ, mas não σ) · Orexina ( 1, 2) · Oxitocina · Procineticina ( 1, 2) · Peptídeo liberador de prolactina · Relaxina ( 1, 2, 3, 4) · Somatostatina ( 1, 2, 3, 4, 5) · Taquicinina ( 1, 2, 3) · Tirotrofina · Hormônio liberador de tirotropina · Urotensina-II · Vasopressina ( 1A, 1B, 2) |
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Miscelânea | Órfão | GPR ( 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183) |
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Outros | Olfatório · Opsina ( 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Ativado por protease ( 1, 2, 3, 4) · SREB ( 1, 2, 3) |
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Classe B: Tipo secretina | Órfãos | GPR ( 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157) |
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Outros | ADCYAP1R1 · Caderina ( 1, 2, 3) · Calcitonina · CALCRL · CD97 · EMR ( 1, 2, 3) · Glucagon ( GR, GIPR, GLP1R, GLP2R) · Hormônio liberador de corticotrofina ( 1, 2) · Hormônio liberador do hormônio do crescimento · Hormônio paratireoide ( 1, 2) · GPR · Inibidor de angiogênese específico do cérebro ( 1, 2, 3) · Latrofilina ( 1, 2, 3, ELTD1 · Peptídeo intestinal vasoativo ( 1, 2) · Proteínas tipo-Matusalém · Secretina |
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Classe C: Metabotrópico glutamato / feromona | Sabor | TAS1R ( 1, 2, 3) · TAS2R ( 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50) |
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Outros | Sensor de cálcio · GABA B ( 1, 2) · Glutamato ( Metabotrópico de glutamato ( 1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR ( 156, 158, 179) · RAIG ( 1, 2, 3, 4) |
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Class F: Frizzled / Smoothened | |
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