Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh ekspor, FDI dan inflasi terhadap pertumbuhan ekonomi di Indonesia. Penelitian ini menggunakan metode analisis VAR indifference. Data yang digunakan ialah data time series dari tahun 1981-2015 yang terkait dengan pertumbuhan ekonomi, ekspor, FDI dan inflasi atas dasar harga konstan. Hasil penelitian menunjukkan (1) ekspor berpengaruh secara signifikan dan negatif terhadap pertumbuhan ekonomi; (2) FDI berpengaruh secara signifikan dan positif terhadap pertumbuhan ekonomi; (3) inflasi berpengaruh secara signifikan dan negatif terhadap …
Pengangguran merupakan salah satu permasalahan yang dihadapi oleh Provinsi Jawa Timur. Untuk menghadapi permasalahan ini pemerintah Provinsi Jawa Timur memandang sektor UMKM meruopakan sektor yang memiliki potensi yang besar dalam pengurangan pengangguran, karena sektor UMKM merupakan sektor utama dalam perekonomian Jawa Timur. Dibalik besarnya peran UMKM Jawa Timur sektor ini masih mengalami berbagai permasalahan. Masalah terbesar yang dihadapi oleh sektor ini adalah masalah permodalan karena sektor perbankan enggan untuk memberikan pinjaman di sektor UMKM karena bentuk usaha yang sebagian no…
Tujuan penelitian ini adalah untuk menguji pengaruh skeptisisme profesional auditor, independensi auditor, integritas auditor, pengalaman dalam tugas audit, dan keahlian yang dimiliki auditor terhadap pemberian opini auditor pada laporan keuangan perusahaan. Sampel penelitian ini dipilih dengan metode convenience sampling. Sampel dalam penelitian ini adalah auditor yang bekerja pada Kantor Akuntan Publik di Malang, Jawa Timur. Penelitian ini menggunakan teknik analisis data regresi berganda (multiple linier regression). Hasil dari penelitian ini menunjukkan bahwa dari lima variabel independen …
Penelitian ini bertujuan untuk melihat pengaruh desentralisasi fiskal terhadap pertumbuhan ekonomimelalui IPM pada kabupaten dan kota di Jawa Timur. Hal ini dipicu oleh pertumbuhan ekonomi diwilayah ini menunjukkan fluktuasi yang cenderung menurun sementara sumberdaya manusia yangdimiliki oleh kabupaten dan kota di Jawa Timur cukup melimpah dan Indeks Pembangunan Manusia(IPM) terus meningkat. Sementara itu PAD, Dana Perimbangan, serta Belanja Daerah merupakanwujud dari desentralisasi fiskal yang merupakan salah satu alat untuk mencapai sebuah tujuan.Metode yang digunakan adalah kuantitatif sek…
It has been known that there are differences in response to medications both in terms of clinical activity and side effects. Among all influencing factors, genetic variation has been considered to play a crucial part. By genetic investigation, the differences in drug metabolism, transport and target could be disclosed. Termed as “pharmacogenetics (PGx)â€, that focuses on the variants within one or more candidate genes. Genetic tests have been started for screening polymorphisms prior to drug prescription, moreover many biomarkers were developed in oncology. Recent PGx investigati…
Leunca (Solanum nigrum L.) has been proven to possess anticancer activity on some type of cancer cells. In vitro study of solamargine found in the herb showed cytotoxic effect against several breast cancer cell lines, such as T47D and MDA-MB-31. Hence, further study on its potential as a co-chemotherapeutic agent needs to be conducted, in order to overcome resistance problem commonly found in cancer chemotherapy. This study aimed to examine the cytotoxic activity of leunca herb ethanolic extract (LEE) alone and its combination with doxorubicin. Single and combinational treatment of LEE and dox…
Due to severe side effect and non-specific chemotherapeutic agent, screening and discovery for cancer therapy are still working, especially from natural resources. Traditionally, people used herbal medicine either to prevent or cure diseases. One of herbal that commonly used in Indonesia is Alpinia galangal. Previous study stated that active compound is acetoxy chavicol acetate (ACA) and active as anticancer. This research aimed to determine ACA concentration and cytotoxic activity of Alpinia galanga extract (AGE) from three local markets on HeLa, MCF7 and T47D cell lines. The galangal used fr…
The study was aimed to investigate the growth inhibiting effect of Plectranthus amboinicus, (Lour.) Spreng n-hexane extract (PAN) in combination with doxorubicin againts HeLa cell Lines, to observe the apoptotic induction and immunocytochemistry of HeLa cell Lines on cyclin D1, Bcl-2, and Cox-2 after treatment of PAN. The percentage viability of the cell were carried out by using MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide] assay. The effect of apoptosis was observed by flowcytometry assay in single dose of PAN. The expression of cyclin D1, Bcl2 and COX-2 proteins were …
Resistance to chemotherapy is believed to cause treatment failure of the patient cancer. Secang (Caesalpinia sappan L.) has been proven to possess anticancer activity on some cancer cell lines. The aimed of this study to develop ethanolic extract of secang wood (EES) as chemosensitizing agent through apoptotic induction on breast cancer MCF-7 cells. Extraction of secang was done by using maceration with 70 % ethanol. Single and combinatorial treatment of EES and doxorubicin on MCF-7 breast cancer cells were analyzed by using MTT assay to determine the IC50 value and combination index (CI) to e…
Trigonella foenum-graecum (TFG) is one of medicinal plants contains some steroidal sapogenin such as diosgenin, yamogenin, gitogenin, tigogenin and trigoneoside, also alkaloid trigonellin, which is have many activity as antidiabetic, estrogenic and also as anti cancer. This experiment was done to explore the activity of some extract of TFG on some cell lines such as MCF7 (Human Breast Cancer Cell-line), T47D (Human Breast Cancer Cell-line), PC3 (Human Prostate Cell-line) and SKOV (Human Ovarian Carcinoma Cell-line). This assay was done using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetraz…
The incidence of Breast Cancer Metastasis (MBC) can be categorized in stage IV as well as being the leading cause of death in cases of breast cancer. MBC prognosis is known to be weak, frequent recurrent, and MBC patients have only a survival rate of about 5 years. One of the proteins that causes breast cancer metastasis is Human Epidermal Growth Factor 2 (HER2). Pentagamaboron-0 (PGB-0), a newly curcumin analogue performed cytotoxic effect on HER2-positive breast cancer cells but it is practically water-insoluble. The aims of this study are to determine anti-metastatic activity of a more s…
Doxorubicin is one of chemotherapeutic agent widely used in breast cancer treatment, but in high dose doxorubicin gives negative side effect, including vomit, nausea, immune suppression, and cardiac toxicity. This toxicity hopefully could be reduced by combination chemotherapy using natural herbs such as ciplukan herb. This research was conducted to explore cytotoxic activity of single ciplukan herbs ethanolic extract and its combination with doxorubicin on T47D breast cancer cells. Cytotoxic activity of ciplukan herbs ethanolic extract only and its combination with doxorubicin were tested on …
DNA damage usually happens due to the several chemical materials that induce genotoxic effect in normal cells. Cinnamon essential oil (CEO), which contains cinnamaldehyde as its major compound, has been reported to possess antioxidant activity to prevent DNA damage. The aim of this study is to evaluate the genotoxic and cytotoxic effect of CEO on doxorubicin-induced Chinese Hamster Ovary (CHO-K1) cells. The cytotoxic effect of CEO was determined by MTT assay with the parameter of IC50 while the genotoxic effect was carried out by micronucleus (MN) assay by using acridine orange fluorescent sta…
The usage of doxorubicin (DOX) as an anticancer drug in cancer patient may cause several side effects. One of that is cardiotoxicity by inducing the expression of nitric oxide synthase which may release nitric oxide (NO) resulting reactive oxygen species (ROS) in the cardiac. DOX needs to be combined with antioxidant since it could supressed ROS in the cardiac and reduce cardiomyopathy. Kelor (Moringa oleifera) is known as the source of antioxidant. This study aim to observe the treatment effects of ethanolic extract of kelor (EEK) on histopathology profile and concentration of NO in rats card…
The research focused on a social construction or interpretation of the Buyut Cili Myth as a storytelling tradition Blambangan history. The research objectives identified socially constructed form of knowledge as well as the values of the Buyut Cili myth. The research method was classroom action research. The result of the research found that Buyut Cili myth was a conceptual instrument for students to understand the concept of historical continuity. The complexity of life was contained in reality which displayed by the Buyut Cili. It proved that social reality was plural or multi-dimension. The…
The objective of the study is to develop the educational model of cultural values based on the classical batikââ¬â¢s Surakarta arts tradition in order to strengthen the nation characters and national identity. The research was done by using the research and development method. In collecting the data, the researcher conducted several ways, as follow: interview, library research, forum group discussion and classroom action research. The qualitative analysis was used for conducting the need analysis as the first step of research and development activity and the quantitative analysis an…
The objective of this study is to examine the Islamic education in Indonesia seeing from the historical perspective, which is focusing on pesantren and madrasah (Islamic schools) from the colonialism era until new order era. Previously, Islamic education dealt with the spread of Islam (moslem) and the Islamized of Indonesian archipelago. It means that the Islamic education was, first, centralized on mosque, langgar or surau (smaller mosque). Next, it changes into other institutions from pesantren salafiyah into madrasah. The latest one has already adopted and applied the science curriculum and…
This research produce a product model of internalization of the character in learning history through Value Clarification Technique as a revitalization of the role of social studies in the formation of national character. In general, this research consist of three levels : (1) doingàpre-survey which identified the current condition ofàthe learning value of character in ââ¬â¹Ã¢â¬â¹in learning history (2) development of a model based on the findings ofàpre-survey, the model used is the Dick and Carey Model, and (3) validating the models. Development m…
This study discussed about the regulation of the Dutch colonial administration for its expansion in Nederlands Nieuw Guinea (NNG) between 1898 and 1962.ÃÂ The arrangement covered the expansion area, uniting and abolition of the government. This process began with the exploration activities, construction of infrastructure facilities and transportation/communication and recruitment of government officials. Construction of transportation and communication made local economy was increase. Government officials who stationed in the region must meet the specific requirements such as fam…
The silver business since the reign of Sri Sultan HB VIII has gained its position in driving the economic progress of Kotagede’s people. The silver industry, besides its economic values, is also a cultural asset of the people of Yogyakarta. From 1935-1938, there were more than 78 silver entrepreneurs with a total annual production of 25 tons of silver. This study aims to determine and to analyze the history of the silver business in Kotagede and the values inherited from the kingdom period to the modern era. This research used the historical method by describing data on the development …