DNA damage usually happens due to the several chemical materials that induce genotoxic effect in normal cells. Cinnamon essential oil (CEO), which contains cinnamaldehyde as its major compound, has been reported to possess antioxidant activity to prevent DNA damage. The aim of this study is to evaluate the genotoxic and cytotoxic effect of CEO on doxorubicin-induced Chinese Hamster Ovary (CHO-K1) cells. The cytotoxic effect of CEO was determined by MTT assay with the parameter of IC50 while the genotoxic effect was carried out by micronucleus (MN) assay by using acridine orange fluorescent staining with the parameter of MN/1000 cells reduction number. Based on MTT assay, CEO showed cytotoxic activity with the IC50 value of 30 μg/ml and for MN assay, 3 μg/ml (1/10 IC50) of CEO decreased the percentage of micronucleus per 1000 cells up to 94,55%. Thus, the result can be summarized that CEO does not induce genotoxic and has the potency to prevent DNA damage caused by doxorubicin on CHO-K1 cells.Keywords: genotoxic, cinnamomum essential oil (CEO), micronuclei assay, in vitro
| Published by | Indonesian Society for Cancer Chemoprevention |
| Journal Name | Indonesian Journal of Cancer Chemoprevention |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA |
| Website | ijcc| https://ijcc.chemoprev.org/index.php/ijcc| |
| ISSN | ISSN : 23558989, EISSN : 20880197, DOI : -, |
| Core Subject | Health, Science, |
| Meta Subject | Biochemistry, Genetics & Molecular Biology, Medicine & Pharmacology, |
| Meta Desc | Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products. |
| Penulis | Wikanthi, Layung Sekar Sih , Wulandari, Nindi , Esti, Yuni Fajar , Sari, Nur Fitra , Susidarti, Ratna Asmah |
| Publisher Article | Indonesian Society for Cancer Chemoprevention |
| Subtitle Article | Indonesian Journal of Cancer Chemoprevention Vol 8, No 1 (2017) |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://ijcc.chemoprev.org/ind… |
| DOI | https://doi.org/10.14499/indonesian… |
| DOI Number | DOI: 10.14499/indonesianjcanchemoprev8iss1pp27-31 |
| Download Article [1] | https://ijcc.chemoprev.org/index.php/ijc… |
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Informasi yang terkait dengan Cinnamomum Essential Oil Prevents DNA Damage Induced by Doxorubicin on CHO K1 Cells
Cinnamomum Cinnamomum burmannii Cinnamomum camphora Kayu manis tiongkok Beruang cinnamon