Trigonella foenum-graecum (TFG) is one of medicinal plants contains some steroidal sapogenin such as diosgenin, yamogenin, gitogenin, tigogenin and trigoneoside, also alkaloid trigonellin, which is have many activity as antidiabetic, estrogenic and also as anti cancer. This experiment was done to explore the activity of some extract of TFG on some cell lines such as MCF7 (Human Breast Cancer Cell-line), T47D (Human Breast Cancer Cell-line), PC3 (Human Prostate Cell-line) and SKOV (Human Ovarian Carcinoma Cell-line). This assay was done using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium) methods. Results showed that ethyl acetate fraction gives the lowest IC50 than another extracts. IC50 for PC3 is 66.24 ppm, IC50 for MCF7 is 41.81 ppm, IC50 for T47D is 58.63 ppm. These datas can be used for further research to isolate the active compound from TFG.Keywords : Trigonella foenum-graecum, MCF-7, T47D, SKOV, PC3
| Published by | Indonesian Society for Cancer Chemoprevention |
| Journal Name | Indonesian Journal of Cancer Chemoprevention |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA |
| Website | ijcc| https://ijcc.chemoprev.org/index.php/ijcc| |
| ISSN | ISSN : 23558989, EISSN : 20880197, DOI : -, |
| Core Subject | Health, Science, |
| Meta Subject | Biochemistry, Genetics & Molecular Biology, Medicine & Pharmacology, |
| Meta Desc | Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products. |
| Penulis | Agustini, Kurnia , Sumaryono, Wahono , Widyanto, R. Micho |
| Publisher Article | Indonesian Society for Cancer Chemoprevention |
| Subtitle Article | Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011) |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://ijcc.chemoprev.org/ind… |
| DOI | https://doi.org/10.14499/indonesian… |
| DOI Number | DOI: 10.14499/indonesianjcanchemoprev2iss2pp234-241 |
| Download Article [1] | https://ijcc.chemoprev.org/index.php/ijc… |
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