NBOMe and NBOHs are regularly sold as LSD in blotter papers,[3][11] which have a bitter taste and different safety profiles.[5][2] Despite high potency, recreational doses of LSD have only produced low incidents of acute toxicity.[2] Fatalities involved in NBOMe intoxication suggest that a significant number of individuals ingested the substance which they believed was LSD,[7] and researchers report that "users familiar with LSD may have a false sense of security when ingesting NBOMe inadvertently".[5] While most fatalities are due to the physical effects of the drug, there have also been reports of death due to self-harm and suicide under the influence of the substance.[12][13][5]
Given limited documentation of NBOMe consumption, the long-term effects of the substance remain unknown.[5] NBOMe compounds are not active orally,[a] and are usually taken sublingually.[15]: 3 When NBOMes are administered sublingually, numbness of the tongue and mouth followed by a metallic chemical taste was observed, and researchers describe this physical side effect as one of the main discriminants between NBOMe compounds and LSD.[16][17][18]
Many of the NBOMe compounds have high potency agonist activity at additional 5-HT receptors and prolonged activation of 5-HT2B can cause cardiac valvulopathy in high doses and chronic use.[3][8] 5-HT2B receptors have been strongly implicated in causing drug-induced valvular heart disease.[19][20][21] The high affinity of NBOMe compounds for adrenergic α1 receptor has been reported to contribute to the stimulant-type cardiovascular effects.[8]
In vitro studies, 25C-NBOMe has been shown to exhibit cytotoxicity on neuronal cell lines SH-SY5Y, PC12, and SN471, and the compound was more potent than methamphetamine at reducing the visibility of the respective cells; the neurotoxicity of the compound involves activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.[4] 25C-NBOMe, including the other derivative 25D-NBOMe, reduced the visibility of cardiomyocytes H9c2 cells, and both substances downregulated expression level of p21 (CDC24/RAC)-activated kinase 1 (PAK1), an enzyme with documented cardiac protective effects.[4]
Preliminary studies on 25C-NBOMe have shown that the substance is toxic to development, heart health, and brain health in zebrafish, rats, and Artemia salina, a common organism for studying potential drug effects on humans, but more research is needed on the topic, the dosages, and if the toxicology results apply to humans. Researchers of the study also recommended further investigation of the drug's potential in damaging pregnant women and their fetus due to the substance's damaging effects to development.[22][23]
^The potency of N-benzylphenethylamines via buccal, sublingual, or nasal absorption is 50-100 greater (by weight) than oral route compared to the parent 2C-x compounds.[14] Researchers hypothesize the low oral metabolic stability of N-benzylphenethylamines is likely causing the low bioavailability on the oral route, although the metabolic profile of this compounds remains unpredictable; therefore researchers state that the fatalities linked to these substances may partly be explained by differences in the metabolism between individuals.[14]
Political proposal A Celtic union or Celtic alliance refers to political unity between the Celtic nations either within the UK or together as independent countries. Historical proposals In 1864, Charles De Gaulle proposed a Celtic Union that would establish and develop links between Celtic countries. There should also be a Celtic Esperanto to facilitate communication and which would be created from common elements in all Celtic languages and a Pan-Celtic festival.[1][2]:̴…
American politician (1827–1918) This article was imported from the Biographical Directory of the United States Congress. Please help improve this article. Ellis H. Roberts20th Treasurer of the United StatesIn officeJuly 1, 1897 – June 30, 1905PresidentWilliam McKinleyTheodore RooseveltPreceded byD.N. MorganSucceeded byCharles H. TreatMember of theU.S. House of Representativesfrom New YorkIn officeMarch 4, 1871 – March 3, 1875Preceded byAlexander H. BaileySucceeded byG…
Human settlement in EnglandThorington StreetThorington StreetLocation within SuffolkCivil parishStoke-by-NaylandDistrictBaberghShire countySuffolkRegionEastCountryEnglandSovereign stateUnited Kingdom List of places UK England Suffolk 51°58′44″N 0°55′41″E / 51.979°N 0.928°E / 51.979; 0.928 Thorington Street is a large hamlet on the B1068 road, in the Babergh district, in the English county of Suffolk.[1] The hamlet is part of the civil parish …
American soccer player Todd Dunivant Personal informationFull name Todd DunivantDate of birth (1980-12-26) December 26, 1980 (age 43)Place of birth Wheat Ridge, Colorado, United StatesHeight 6 ft 0 in (1.83 m)Position(s) DefenderTeam informationCurrent team Sacramento Republic (general manager)College careerYears Team Apps (Gls)1999–2002 Stanford Cardinal Senior career*Years Team Apps (Gls)2002 Boulder Rapids Reserve 2003–2004 San Jose Earthquakes 46 (1)2005–2006 LA Gal…
Pour les articles homonymes, voir Compagnie de Rouen. Cet article est une ébauche concernant la Nouvelle-France. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Compagnie de RouenCadreType Compagnie colonialePays Royaume de Francemodifier - modifier le code - modifier Wikidata Sous les auspices du prince de Condé, vice-roi de Nouvelle-France (1612-1620), Samuel de Champlain forma la Compagnie des marchands de Roue…
Questa voce sull'argomento stagioni delle società calcistiche italiane è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Voce principale: Unione Sportiva Calcio Trani. Associazione Polisportiva TraniStagione 1971-1972Sport calcio Squadra Trani Allenatore Sergio Ballarin Presidente Francesco Sorrenti Serie C3º nel girone C. Maggiori presenzeCampionato: Sorge (37) Miglior marcatoreCampionato: Somma (8) …
Kabupaten YalimoKabupatenRuas Trans Papua Elelim LambangMotto: Nori ManiekPetaKabupaten YalimoPetaTampilkan peta Maluku dan PapuaKabupaten YalimoKabupaten Yalimo (Indonesia)Tampilkan peta IndonesiaKoordinat: 3°47′06″S 139°26′49″E / 3.785°S 139.447°E / -3.785; 139.447Negara IndonesiaProvinsiPapua PegununganTanggal berdiri4 Januari 2008Dasar hukumUU RI Tahun 2008 No.4Ibu kotaElelimJumlah satuan pemerintahan Daftar Distrik: 5Kampung: 300 Pemerintahan…
بول رومر (بالإنجليزية: Paul Michael Romer) معلومات شخصية الميلاد 6 نوفمبر 1955 (69 سنة)[1] دنفر مواطنة الولايات المتحدة عضو في الأكاديمية الأمريكية للفنون والعلوم، وجمعية الاقتصاد القياسي [لغات أخرى][2] الأب روي رومر الحياة العملية المدرسة ال…
As of completion of the 2023–24 season – the 106th regular season of play of the National Hockey League (NHL) – 46 different ice hockey players have scored at least 500 regular season goals in their NHL career. A 500-goal career was first achieved in the 44th year of the NHL (1957–58), when Maurice Richard scored his 500th goal in his 938th game. Season achievements The 2006–07 season saw the largest number of players (five) achieve their 500th goal …
BalmeKomuneComune di BalmeNegaraItaliaWilayahPiedmontProvinsiProvinsi Torino (TO)Luas • Total63,1 km2 (244 sq mi)Ketinggian1.432 m (4,698 ft)Populasi (Desember 2004) • Total98 • Kepadatan0,16/km2 (0,40/sq mi)Zona waktuUTC+1 (CET) • Musim panas (DST)UTC+2 (CEST)Kode pos10070Kode area telepon0123 Balme adalah komune yang terletak di distrik Provinsi Torino, Italia. Kota Balme memiliki luas sebesar 63.1 km². Ba…
Gutka adalah sebuah jenis tembakau kunyah khas India yang dicampur dengan pinang, kapur, parafiin dan bahan lainnya. Beberapa jenis Gutka juga mengandung bahan beracun atau logam berat timbal, arsenik, krom, nikel dan kadmium. Karena rasanya yang manis atau rasa coklat serta harganya yang sangat murah, Gutka populer di kalangan anak-anak yang juga mengunyahnya bahkan memakannya. Lima juta anak India telah kecanduan Gutkha, dan angka kecanduan di kalangan anak-anak meningkat rata-rata 5.000 anak …
American politician Bates Cooke11th New York State ComptrollerIn office1839–1841GovernorWilliam H. SewardPreceded byAzariah C. FlaggSucceeded byJohn A. CollierMember of the U.S. House of Representativesfrom New York's 30th districtIn officeMarch 4, 1831 – March 3, 1833Preceded byEbenezer F. NortonSucceeded byPhilo C. Fuller Personal detailsBorn(1787-12-23)December 23, 1787Wallingford, ConnecticutDiedMay 31, 1841(1841-05-31) (aged 53)Lewiston, New YorkPolitical p…
Control by foreign groups This article is about practice of colonialism. For practice of indirect colonialism or the continuation of colonial relations, see Neocolonialism. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Colonialism – news · newspapers · books · scholar · JSTOR (April 2021) (Learn how and when …
Australian electorate WyongNew South Wales—Legislative AssemblyInteractive map of district boundaries from the 2023 state electionStateNew South WalesDates current1962–19731988–presentMPDavid HarrisPartyLabor PartyNamesakeWyongElectors57,477 (2019)Area640.55 km2 (247.3 sq mi)DemographicProvincial Electorates around Wyong: Cessnock Lake Macquarie Swansea Gosford Wyong Pacific Ocean Gosford The Entrance The Entrance Wyong is an electoral district of the Legislative Assemb…
Railway museum in Kitakyushu, Japan Kyushu Railway History Museum九州鉄道記念館The museum's entranceLocation of the museumShow map of Fukuoka PrefectureKyushu Railway History Museum (Japan)Show map of JapanEstablished9 August 2003LocationKitakyushu, JapanCoordinates33°56′35″N 130°57′42″E / 33.94317°N 130.96179°E / 33.94317; 130.96179TypeRailway museumDirectorMasaaki Sato (佐藤正昭)Public transit accessMojikō StationWebsitewww.k-rhm.jp The Kyushu Ra…
2015 eidtion of the EuroBasket Women International basketball competition EuroBasket 2015 Women35th FIBA European Women'sBasketball ChampionshipTournament detailsHost countries Hungary RomaniaDates11–28 JuneTeams20Venue(s)7 (in 7 host cities)Final positionsChampions Serbia (1st title)Tournament statisticsMVP Ana Dabović[1]Top scorer Torrens (19.7)Top rebounds Leuchanka (11.5)Top assists Škerović (7.1)← 2013 2017 → The 2015 European Women Bas…
BandengRentang fosil: 100–0 jtyl PreЄ Є O S D C P T J K Pg N Zaman kapur awal–sekarang Status konservasi Risiko Rendah (IUCN 3.1)[1] Klasifikasi ilmiah Domain: Eukaryota Kerajaan: Animalia Filum: Chordata Kelas: Actinopterygii Ordo: Gonorynchiformes Famili: Chanidae Genus: ChanosLacépède, 1803 Spesies: Chanos chanosForsskål, 1775 Sinonim Butirinus argenteus Jerdon, 1849 Butirinus maderaspatensis Jerdon, 1849 Chanos arabicus Lacepède, 1803 Chanos chloropterus Valencie…
American politician (born 1977) Nancy MaceOfficial portrait, 2020Member of the U.S. House of Representativesfrom South Carolina's 1st districtIncumbentAssumed office January 3, 2021Preceded byJoe CunninghamMember of the South Carolina House of Representativesfrom the 99th districtIn officeJanuary 23, 2018 – November 8, 2020Preceded byJames MerrillSucceeded byMark Smith Personal detailsBornNancy Ruth Mace (1977-12-04) December 4, 1977 (age 46)Fort Bragg…
1947 film by William A. Seiter I'll Be Yourstheatrical release posterDirected byWilliam A. SeiterWritten byFeliz Johnson (adaptation)Screenplay byPreston SturgesBased onA jó tündérby Ferenc MolnárProduced byFelix JacksonStarring Deanna Durbin Tom Drake William Bendix Adolphe Menjou CinematographyHal MohrEdited byOtto LudwigMusic byFrank SkinnerProductioncompanyUniversal PicturesDistributed byUniversal PicturesRelease date February 2, 1947 (1947-02-02) (US) Running time93 m…