SR-57227

SR-57227

Identifiers
IUPAC name 1-(6-chloropyridin-2-yl)piperidin-4-amine
CAS Number	77145-61-0
PubChem CID	131747
IUPHAR/BPS	4316
ChemSpider	116402
UNII	OW45B79UZD
CompTox Dashboard (EPA)	DTXSID8046953 DTXSID5045201, DTXSID8046953
ECHA InfoCard	100.163.915
Chemical and physical data
Formula	C10H14ClN3
Molar mass	211.69 g·mol^−1
3D model (JSmol)	Interactive image
SMILES ClC1=CC=CC(N2CCC(N)CC2)=N1
InChI InChI=1S/C10H14ClN3/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14/h1-3,8H,4-7,12H2 Key:WPVVMKYQOMJPIN-UHFFFAOYSA-N

SR-57227 is a potent and selective agonist at the 5HT₃ receptor, with high selectivity over other serotonin receptor subtypes and good blood–brain barrier penetration.[1][2][3][4]

References

1. Bachy A, Héaulme M, Giudice A, Michaud JC, Lefevre IA, Souilhac J, et al. (June 1993). "SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo". European Journal of Pharmacology. 237 (2–3): 299–309. doi:10.1016/0014-2999(93)90282-M. PMID 7689975.
2. Maksay G, Simonyi M, Bikádi Z (October 2004). "Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists". Journal of Computer-Aided Molecular Design. 18 (10): 651–64. doi:10.1007/s10822-004-6259-0. PMID 15849995. S2CID 10510254.
3. Yoo JH, Cho JH, Yu HS, Lee KW, Lee BH, Jeong SM, et al. (November 2006). "Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study". Journal of Neurochemistry. 99 (3): 976–88. doi:10.1111/j.1471-4159.2006.04137.x. PMID 16942594. S2CID 38685481.
4. Li Y, Raaby KF, Sánchez C, Gulinello M (November 2013). "Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats". Behavioural Brain Research. 256: 520–8. doi:10.1016/j.bbr.2013.09.002. PMID 24016840. S2CID 45617581.