4-AcO-MET

4-AcO-MET
Clinical data
Other names	4-Acetoxy-MET; Metacetin; 4-Acetoxy-N-methyl-N-ethyltryptamine
Identifiers
	IUPAC name [3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate;
CAS Number	1445751-40-5;
PubChem CID	71308138;
ChemSpider	26633897;
UNII	PCJ17NV1P0;
CompTox Dashboard (EPA)	DTXSID301029955 ;
Chemical and physical data
Formula	C15H20N2O2
Molar mass	260.337 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(C)CCc1c[nH]c2c1c(ccc2)OC(=O)C;
	InChI InChI=1S/C15H20N2O2/c1-4-17(3)9-8-12-10-16-13-6-5-7-14(15(12)13)19-11(2)18/h5-7,10,16H,4,8-9H2,1-3H3; Key:OMDKHOOGGJRLLX-UHFFFAOYSA-N;

4-acetoxy-MET (4-acetoxy-N-methyl-N-ethyl tryptamine), also known as 4-AcO-MET or metacetin, is a hallucinogenic tryptamine. It is the acetate ester of 4-HO-MET, and a homologue of 4-AcO-DMT. It is a novel compound with very little history of human use.^[1] It is sometimes sold as a research chemical by online retailers.

Due to its similarity to the psilocin prodrug 4-AcO-DMT, which is deacetylated to form psilocin in vivo,^[2]^[3] it is expected that 4-AcO-MET is also quickly hydrolyzed into 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.

Legality

In the United States, 4-Acetoxy-MET is not scheduled. It may be considered an analogue of psilocin, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical purposes could be considered a crime under the Federal Analogue Act.^[4]

In Switzerland, 4-Acetoxy-MET is a controlled substance under Verzeichnis E.^[5]

In the United Kingdom, 4-Acetoxy-MET is a Class A drug in the UK because it is an ester of the drug 4-HO-MET, which is a Class A drug under the tryptamine catch-all clause.^[6]