JTE 7-31

JTE 7-31

Names
Preferred IUPAC name 2-[2-(4-Hydroxyphenyl)ethyl]-5-methoxy-4-(pentylamino)-2,3-dihydro-1H-isoindol-1-one
Identifiers
CAS Number	194358-72-0^Y
3D model (JSmol)	Interactive image
ChemSpider	13767708^Y
PubChem CID	19363402
UNII	7MV5OX2NX0^Y
CompTox Dashboard (EPA)	DTXSID50598386
InChI InChI=1S/C22H28N2O3/c1-3-4-5-13-23-21-19-15-24(14-12-16-6-8-17(25)9-7-16)22(26)18(19)10-11-20(21)27-2/h6-11,23,25H,3-5,12-15H2,1-2H3^Y Key: FMUMUYFMLZGXJR-UHFFFAOYSA-N^Y InChI=1/C22H28N2O3/c1-3-4-5-13-23-21-19-15-24(14-12-16-6-8-17(25)9-7-16)22(26)18(19)10-11-20(21)27-2/h6-11,23,25H,3-5,12-15H2,1-2H3 Key: FMUMUYFMLZGXJR-UHFFFAOYAA
SMILES Oc1ccc(cc1)CCN3Cc2c(ccc(OC)c2NCCCCC)C3=O
Properties
Chemical formula	C22H28N2O3
Molar mass	368.469 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

JTE 7-31 is a selective cannabinoid receptor agonist invented by Japan Tobacco.[1][2] It is a reasonably highly selective CB₂ agonist, but still retains appreciable affinity at CB₁, with a K_i of 0.088nM at CB₂ vs 11nM at CB₁.[3]

Legality

JTE 7-31 is illegal in Alabama.[4]

See also

• A-834,735
• JTE-907
• MDA-19
• N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide
• S-444,823
• XLR-12

References

1. WO patent 1997/029079, Inaba T, Kaya T, Iwamura H, "Novel compounds and pharmaceutical use thereof", granted 1997-14-08 
2. US patent 6017919, Inaba T, Kaya T, Iwamura H, "Compounds and pharmaceutical use thereof", granted 2000-01-25 
3. Han S, Zhang FF, Qian HY, Chen LL, Pu JB, Xie X, Chen JZ (March 2015). "Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor". European Journal of Medicinal Chemistry. 93: 16–32. doi:10.1016/j.ejmech.2015.01.054. PMID 25644673.
4. "Alabama Senate Bill SB 333: Controlled Substances" (PDF).

External links