CUMYL-THPINACA

CUMYL-THPINACA

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B Illegal in China and Sweden
Identifiers
IUPAC name 1-(oxan-4-ylmethyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide
CAS Number	1400742-50-8^Y
PubChem CID	86273679
ChemSpider	48057932
UNII	6R5GTC3QVB
CompTox Dashboard (EPA)	DTXSID401032565
Chemical and physical data
Formula	C23H27N3O2
Molar mass	377.488 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(NC(C)(C)C1=CC=CC=C1)C2=NN(CC3CCOCC3)C4=C2C=CC=C4
InChI InChI=1S/C23H27N3O2/c1-23(2,18-8-4-3-5-9-18)24-22(27)21-19-10-6-7-11-20(19)26(25-21)16-17-12-14-28-15-13-17/h3-11,17H,12-16H2,1-2H3,(H,24,27) Key:HINCNLQQLQFMRD-UHFFFAOYSA-N

CUMYL-THPINACA (also known as SGT-42) is an indazole-3-carboxamide based synthetic cannabinoid.[1][2] CUMYL-THPINACA acts as a potent agonist for the cannabinoid receptors, with approximately 6x selectivity for CB₁, having an EC₅₀ of 0.1nM for human CB₁ receptors and 0.59nM for human CB₂ receptors.[3]

Legal status

Sweden's public health agency suggested to classify CUMYL-THPINACA as hazardous substance on November 10, 2014.[4]

As of October 2015 CUMYL-THPINACA is a controlled substance in China.[5]

See also

• 5F-CUMYL-PINACA
• 5F-SDB-006
• ADAMANTYL-THPINACA
• CUMYL-4CN-BINACA
• CUMYL-CBMINACA
• CUMYL-PICA
• CUMYL-PINACA
• SDB-006
• NNE1

References

1. "CUMYL-THPINACA". Cayman Chemical. Retrieved 11 July 2015.
2. Monti MC, Scheurer E, Mercer-Chalmers-Bender K (July 2021). "Phase I In Vitro Metabolic Profiling of the Synthetic Cannabinoid Receptor Agonists CUMYL-THPINACA and ADAMANTYL-THPINACA". Metabolites. 11 (8): 470. doi:10.3390/metabo11080470. PMC 8398790. PMID 34436411.
3. WO 2014167530, Bowden MJ, Williamson JP, "Cannabinoid compounds", published 2014-10-16 
4. "Cannabinoider föreslås bli klassade som hälsofarlig vara". Retrieved 11 July 2015.
5. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.