Clortermine

Clortermine

Clinical data
Other names	2-chloro-α,α-dimethylphenethylamine; 2-chloro-α-methylamphetamine; 2-chlorophentermine
Pregnancy category	?
Routes of administration	Oral
ATC code	none
Legal status
Legal status	US: Schedule III In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-(2-chlorophenyl)-2-methylpropan-2-amine
CAS Number	10389-73-8^N
PubChem CID	25223
DrugBank	DB01527^Y
ChemSpider	23558^Y
UNII	4FA88HM3IX
KEGG	D03566^Y
ChEMBL	ChEMBL1697833^N
CompTox Dashboard (EPA)	DTXSID0022850
Chemical and physical data
Formula	C10H14ClN
Molar mass	183.68 g·mol^−1
3D model (JSmol)	Interactive image
SMILES Clc1ccccc1CC(N)(C)C
InChI InChI=1S/C10H14ClN/c1-10(2,12)7-8-5-3-4-6-9(8)11/h3-6H,7,12H2,1-2H3^Y Key:HXCXASJHZQXCKK-UHFFFAOYSA-N^Y
^NY (what is this?)  (verify)

Clortermine (Voranil) was developed by Ciba in the 1960s[1] and is an anorectic drug of the amphetamine class.[2] It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,[3] and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.^[citation needed]

See also

• 3,4-Dichloroamphetamine
• Cericlamine
• Chlorphentermine
• Cloforex
• Etolorex
• Methylenedioxyphentermine
• Phentermine

References

1. US patent 3415937, "The Suppression of Appetite with 1-(o-Chlorophenyl)-2-Methyl-2-Propylamine" 
2. Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall / CRC. ISBN 0-412-46630-9.
3. Sannerud CA, Brady JV, Griffiths RR (1989). "Self-injection in baboons of amphetamines and related designer drugs". NIDA Research Monograph. 94: 30–42. PMID 2514366.