4-Benzylpiperidine is a drug and research chemical used in scientific studies. It acts as a monoaminereleasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an EC50 of 109 nM (DA), 41.4 nM (NE) and 5246 nM (5-HT).[1] It has a fast onset of action and a short duration.[1] It also functions as a monoamine oxidaseinhibitor (MAOI) with preference for MAO-A.[2]
RMI-10608 [35623-04-2] Patent (Ex 2/3):[5] (Ex 3)[6] This analogue of haloperidol was discovered to have utility in treating both psychosis as well as preventing brain damage by virtue of its NMDA antagonist pharmacology.
^Arai Y, Hamamichi N, Kinemuchi H (October 1986). "Time-dependent inhibition of rat brain monoamine oxidase by an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine". Neuroscience Letters. 70 (2): 255–260. doi:10.1016/0304-3940(86)90473-8. PMID3490636. S2CID30243106.
^Hoshikawa T, Inoue M (2013). "Photoinduced direct 4-pyridination of C(sp3)–H Bonds". Chemical Science. 4 (8): 3118. doi:10.1039/c3sc51080h. ISSN2041-6520.