Kinase DAP


Kinase DAP (bahasa Inggris: death-associated protein kinase, DAP kinase) adalah sejenis enzim serina kinase/threonina kinase yang berperan dalam apoptosis yang diinduksi oleh interferon-γ, TNF-α dan ligan Fas.

Hipermetilasi enzim,[1] dan metilasi DNA[2] yang menekan ekspresi normal enzim, mengakibatkan sel B,[1] sel T, sel NK, sel NKT[2] berubah menjadi ganas.

Rujukan

  1. ^ a b (Inggris) "[Hypermethylation of DAP-kinase gene CpG Island in malignant lymphoma with B-cell phenotype]". Department of Pathology, Osaka University Graduate School of Medicine; Nakatsuka S, Takakuwa T, Aozasa K. Diakses tanggal 2010-08-02. 
  2. ^ a b (Inggris) "Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T- and natural killer (NK)/T-cell malignancies". Department of Pathology, Osaka University Graduate School of Medicine; Nakatsuka S, Takakuwa T, Tomita Y, Hoshida Y, Nishiu M, Yamaguchi M, Nishii K, Yang WI, Aozasa K. Diakses tanggal 2010-08-02. 


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