Lipoprotein lipase

Lipoprotein lipase (bahasa Inggris: clearing factor lipase; diglyceride lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor, triacylglycero-protein acylhydrolase, LPL, EC 3.1.1.34) merupakan enzim jenis lipase yang mempercepat reaksi hidrolisis pada digliserida, dan trigliserida yang terdapat pada silomikron, LDL,[1] dan VLDL,[2] dengan apoC-II sebagai kofaktor.[3]


Reaksi yang dikatalis,


ANGPTL-3 merupakan senyawa penghambat LPL yang sangat efektif, oleh karena ANGPTL-3 akan meningkatkan reaksi irisan LPL pada lintasan enzimatik furin dan PACE-4 dengan hormon proteglikan heparan sulfat atau GPIHBP-1.[4]


Rujukan

  1. ^ (Inggris) "EC 3.1.1.34". Queen Mary University of London. Diakses tanggal 2011-05-07. 
  2. ^ (Inggris) "Hypertriglyceridemia: its etiology, effects and treatment". Schulich School of Medicine and Dentistry, University of Western Ontario; George Yuan, Khalid Z. Al-Shali, and Robert A. Hegele. Diakses tanggal 2011-05-03. 
  3. ^ (Inggris) "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Department of Biochemistry, College of Science, Protein Network Research Center, Yonsei University; Kim SY, Park SM, Lee ST. Diakses tanggal 2011-05-07. 
  4. ^ (Inggris) "Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases". Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine; Liu J, Afroza H, Rader DJ, Jin W. Diakses tanggal 2011-05-08. 

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