SEC24A

SEC24A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NUP, 2NUT, 3EGD, 3EGX
Identifiers
Aliases	SEC24A, SEC24 homolog A, COPII coat complex component
External IDs	OMIM: 607183; MGI: 1924621; HomoloGene: 70131; GeneCards: SEC24A; OMA:SEC24A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	134,727,909 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	51,654,461 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; oocyte; ; cartilage tissue; ; parotid gland; ; oral cavity; ; secondary oocyte; ; Epithelium of choroid plexus; ; tail of epididymis; ; tibia;
	Top expressed in
	epithelium of small intestine; ; seminal vesicula; ; left lobe of liver; ; migratory enteric neural crest cell; ; salivary gland; ; lacrimal gland; ; submandibular gland; ; body of femur; ; lobe of prostate; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; zinc ion binding; metal ion binding;
Cellular component	cytoplasm; endoplasmic reticulum membrane; membrane; Golgi membrane; endoplasmic reticulum; COPII vesicle coat; cytosol; ER to Golgi transport vesicle membrane; cytoplasmic vesicle;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII vesicle coating; positive regulation of protein secretion; protein transport; intracellular protein transport; vesicle-mediated transport; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII-coated vesicle cargo loading; cholesterol homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	10802
	77371
	ENSG00000113615
	ENSMUSG00000036391
	O95486
	Q3U2P1
	NM_001252231; NM_021982
	NM_001290785; NM_175255
	NP_001239160; NP_068817
	NP_001277714; NP_780464
	Wikidata
View/Edit Human	View/Edit Mouse

SEC24 family, member A (S. cerevisiae) is a protein that in humans is encoded by the SEC24A gene.^[5] The protein belongs to a protein family that are homologous to yeast Sec24.^[6] It is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113615 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036391 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "SEC24 family, member A (S. cerevisiae)". Retrieved 2011-12-05.
^ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (May 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochemical and Biophysical Research Communications. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.