RPS6KA4

RPS6KA4
Identifiers
Aliases	RPS6KA4, MSK2, RSK-B, S6K-alpha-4, ribosomal protein S6 kinase A4
External IDs	OMIM: 603606; MGI: 1930076; HomoloGene: 69288; GeneCards: RPS6KA4; OMA:RPS6KA4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,359,148 bp[1] End 64,372,215 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,806,578 bp[2] End 6,818,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte monocyte right frontal lobe apex of heart right coronary artery mucosa of transverse colon cingulate gyrus prefrontal cortex anterior cingulate cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity protein binding ATP binding magnesium ion binding Cellular component nucleoplasm nucleus cytoplasm cytosol Biological process intracellular signal transduction regulation of transcription, DNA-templated phosphorylation positive regulation of histone acetylation interleukin-1-mediated signaling pathway protein phosphorylation positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor activity inflammatory response negative regulation of cytokine production positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8986 56613 Ensembl ENSG00000162302 ENSMUSG00000118668 UniProt O75676 Q9Z2B9 RefSeq (mRNA) NM_001006944 NM_001300802 NM_003942 NM_001318361 NM_019924 RefSeq (protein) NP_001006945 NP_001287731 NP_001305290 NP_003933 NP_064308 Location (UCSC) Chr 11: 64.36 – 64.37 Mb Chr 19: 6.81 – 6.82 Mb PubMed search [3] [4]
Wikidata
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Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[5][6][7]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]

Interactions

RPS6KA4 has been shown to interact with MAPK14.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000162302 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000118668 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677.
6. Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
7. "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4".

Further reading

• Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science. 273 (5277): 959–963. Bibcode:1996Sci...273..959X. doi:10.1126/science.273.5277.959. PMID 8688081. S2CID 22226803.
• Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377–32379. doi:10.1074/jbc.273.49.32377. PMID 9829964.
• Tomás-Zuber M, Mary JL, Lesslauer W (2000). "Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor". J. Biol. Chem. 275 (31): 23549–23558. doi:10.1074/jbc.M002586200. PMID 10806207.
• Tomás-Zuber M, Mary JL, Lamour F, et al. (2001). "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)". J. Biol. Chem. 276 (8): 5892–5899. doi:10.1074/jbc.M005822200. PMID 11035004.
• Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene. 19 (54): 6324–6333. doi:10.1038/sj.onc.1204007. PMID 11175347.
• Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–5178. doi:10.1128/MCB.21.15.5169-5178.2001. PMC 87241. PMID 11438671.
• Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts". Mol. Cell. Biol. 22 (8): 2871–2881. doi:10.1128/MCB.22.8.2871-2881.2002. PMC 133730. PMID 11909979.
• Soloaga A, Thomson S, Wiggin GR, et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. PMC 156769. PMID 12773393.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–547. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.
• Gesser B, Johansen C, Rasmussen MK, et al. (2007). "Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect". J. Invest. Dermatol. 127 (9): 2129–2137. doi:10.1038/sj.jid.5700859. PMID 17495961.