PRKD2

PRKD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2COA, 3BGM, 4NNX, 4NNY
Identifiers
Aliases	PRKD2, PKD2, nPKC-D2, HSPC187, protein kinase D2
External IDs	OMIM: 607074; MGI: 2141917; HomoloGene: 9516; GeneCards: PRKD2; OMA:PRKD2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,717,127 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,604,389 bp
RNA expression pattern
	Top expressed in
	vena cava; ; superficial temporal artery; ; Skeletal muscle tissue of rectus abdominis; ; granulocyte; ; spleen; ; body of tongue; ; pylorus; ; lactiferous duct; ; cardia; ; skin of leg;
	Top expressed in
	thymus; ; granulocyte; ; mesenteric lymph nodes; ; spleen; ; blood; ; primary oocyte; ; right lung; ; right lung lobe; ; left lung; ; external carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein kinase C activity; metal ion binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity; protein kinase C binding;
Cellular component	cytoplasm; Golgi apparatus; membrane; nucleoplasm; nucleus; cytosol; plasma membrane; intracellular anatomical structure;
Biological process	positive regulation of vascular endothelial growth factor receptor signaling pathway; intracellular signal transduction; positive regulation of endothelial cell proliferation; adaptive immune response; phosphorylation; immune system process; endothelial tube morphogenesis; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of T cell receptor signaling pathway; positive regulation of endothelial cell chemotaxis; positive regulation of DNA-binding transcription factor activity; cell death; protein kinase D signaling; positive regulation of intracellular signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of endothelial cell migration; protein phosphorylation; positive regulation of histone deacetylase activity; positive regulation of CREB transcription factor activity; vascular endothelial growth factor receptor signaling pathway; cell adhesion; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-2 production; angiogenesis; positive regulation of interleukin-8 production; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; protein autophosphorylation; cellular response to vascular endothelial growth factor stimulus; T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of cell adhesion; sphingolipid biosynthetic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	25865
	101540
	ENSG00000105287
	ENSMUSG00000041187
	Q9BZL6
	Q8BZ03
	NM_001079880; NM_001079881; NM_001079882; NM_016457
	NM_001252458; NM_178900
	NP_001073349; NP_001073350; NP_001073351; NP_057541
	NP_001239387; NP_849231
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases, a subfamily of protein kinase C. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.^[7]