MAP2K2

MAP2K2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S9I, 4H3Q
Identifiers
Aliases	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
External IDs	OMIM: 601263; MGI: 1346867; HomoloGene: 48591; GeneCards: MAP2K2; OMA:MAP2K2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,124,122 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,969,809 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right testis; ; left testis; ; apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; right frontal lobe; ; anterior pituitary; ; right hemisphere of cerebellum; ; prefrontal cortex;
	Top expressed in
	muscle of thigh; ; lip; ; right kidney; ; yolk sac; ; neural tube; ; ventricular zone; ; duodenum; ; esophagus; ; superior frontal gyrus; ; Rostral migratory stream;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; PDZ domain binding; scaffold protein binding; protein serine/threonine kinase activator activity; metal ion binding; kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; MAP kinase kinase activity; protein serine/threonine kinase activity;
Cellular component	late endosome; Golgi apparatus; membrane; focal adhesion; cell-cell junction; peroxisomal membrane; extracellular region; early endosome; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; cytoplasmic side of plasma membrane; microtubule; nucleus; cytoplasm; cytosol; plasma membrane;
Biological process	phosphorylation; regulation of early endosome to late endosome transport; peptidyl-serine autophosphorylation; negative regulation of gene expression; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; peptidyl-tyrosine phosphorylation; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; MAPK cascade; ERK1 and ERK2 cascade; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5605
	26396
	ENSG00000126934
	ENSMUSG00000035027
	P36507
	Q63932
	NM_030662
	NM_023138; NM_001347144; NM_001358539
	NP_109587
	NP_001334073; NP_075627; NP_001345468
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.^[5] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.^[6]

Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.^[7]

Interactions

MAP2K2 has been shown to interact with MAPK3^[8]^[9]^[10] and ARAF.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126934 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035027 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem. 268 (15): 11435–9. doi:10.1016/S0021-9258(18)82142-1. PMID 8388392.
^ "MAP2K2 mitogen-activated protein kinase kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2015-10-16.
^ "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2".
^ Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel T P, Kyriakis J M, Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. 272 (5). UNITED STATES: 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895.
^ Butch ER, Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. 271 (8). UNITED STATES: 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767.
^ Zheng CF, Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. 268 (32). UNITED STATES: 23933–9. doi:10.1016/S0021-9258(20)80474-8. ISSN 0021-9258. PMID 8226933.
^ Yin XL, Chen She, Yan Jun, Hu Yun, Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta. 1589 (1). Netherlands: 71–6. doi:10.1016/S0167-4889(01)00188-4. ISSN 0006-3002. PMID 11909642.

External links

GeneReviews/NCBI/NIH/UW entry on Cardiofaciocutaneous Syndrome
Overview of all the structural information available in the PDB for UniProt: P36507 (Dual specificity mitogen-activated protein kinase kinase 2) at the PDBe-KB.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126934 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8388392-5] Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem. 268 (15): 11435–9. doi:10.1016/S0021-9258(18)82142-1. PMID 8388392.

[6] "MAP2K2 mitogen-activated protein kinase kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2015-10-16.

[7] "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2".

[pmid9006895-8] Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel T P, Kyriakis J M, Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. 272 (5). UNITED STATES: 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895.

[pmid8626767-9] Butch ER, Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. 271 (8). UNITED STATES: 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767.

[pmid8226933-10] Zheng CF, Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. 268 (32). UNITED STATES: 23933–9. doi:10.1016/S0021-9258(20)80474-8. ISSN 0021-9258. PMID 8226933.

[pmid11909642-11] Yin XL, Chen She, Yan Jun, Hu Yun, Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta. 1589 (1). Netherlands: 71–6. doi:10.1016/S0167-4889(01)00188-4. ISSN 0006-3002. PMID 11909642.

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MAP2K2

Function

Interactions

References

Further reading

External links

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