Glucosylceramide beta-1,4-galactosyltransferase

Glucosylceramide beta-1,4-galactosyltransferase
Identifiers
EC no.2.4.1.274
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Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274, lactosylceramide synthase, uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Involved in the synthesis of several different major classes of glycosphingolipids.

References

  1. ^ Chatterjee S, Castiglione E (January 1987). "UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes". Biochimica et Biophysica Acta. 923 (1): 136–42. doi:10.1016/0304-4165(87)90136-X. PMID 3099851.
  2. ^ Trinchera M, Fiorilli A, Ghidoni R (March 1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase". Biochemistry. 30 (10): 2719–24. doi:10.1021/bi00224a021. PMID 1900430.
  3. ^ Chatterjee S, Ghosh N, Khurana S (April 1992). "Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney". The Journal of Biological Chemistry. 267 (10): 7148–53. doi:10.1016/S0021-9258(19)50550-6. PMID 1551920.
  4. ^ Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N (May 1998). "Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain". The Journal of Biological Chemistry. 273 (22): 13570–7. doi:10.1074/jbc.273.22.13570. PMID 9593693.
  5. ^ Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N (May 1999). "cDNA cloning and expression of human lactosylceramide synthase". Biochimica et Biophysica Acta. 1438 (2): 301–4. doi:10.1016/S1388-1981(99)00051-7. PMID 10320813.


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