B3GAT2

B3GAT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D0J
Identifiers
Aliases	B3GAT2, GLCATS, beta-1,3-glucuronyltransferase 2
External IDs	OMIM: 607497; MGI: 2389490; HomoloGene: 50574; GeneCards: B3GAT2; OMA:B3GAT2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	70,957,060 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	23,888,239 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; entorhinal cortex; ; ganglionic eminence; ; buccal mucosa cell; ; pons; ; Brodmann area 46; ; postcentral gyrus; ; hippocampus proper; ; endothelial cell; ; corpus callosum;
	Top expressed in
	proximal tubule; ; right kidney; ; ventricular zone; ; urethra; ; human kidney; ; zygote; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; metal ion binding; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	glycosaminoglycan metabolic process; protein glycosylation; chondroitin sulfate proteoglycan biosynthetic process; chondroitin sulfate metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	135152
	280645
	ENSG00000112309
	ENSMUSG00000026156
	Q9NPZ5
	P59270
	NM_080742
	NM_172124
	NP_542780
	NP_742122
	Wikidata
View/Edit Human	View/Edit Mouse

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 is an enzyme that in humans is encoded by the B3GAT2 gene.^[5]^[6]

The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.^[6]

Use of HNK-1 Antibody for Neural Crest Research

Antibodies raised against the HNK-1 epitope have played a large role in studies of the neural crest, especially in the avian embryo.^[7] The first antibody raised against this epitope was NC-1,^[8] which permitted much easier analyses of neural crest migration pathways. In avians, and especially in other vertebrates, the results of HNK-1 staining should be interpreted with caution as the epitope is not unique to the neural crest.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112309 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026156 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T (Oct 2002). "cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope". Gene. 296 (1–2): 29–36. doi:10.1016/S0378-1119(02)00840-5. PMID 12383500.
^ ^a ^b "Entrez Gene: B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)".
^ Bronner-Fraser M (May 1986). "Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1". Dev. Biol. 115 (1): 44–55. doi:10.1016/0012-1606(86)90226-5. PMID 3516760.
^ Vincent M, Thiery JP (June 1984). "A cell surface marker for neural crest and placodal cells: further evolution in peripheral and central nervous system". Dev. Biol. 103 (2): 468–81. doi:10.1016/0012-1606(84)90334-8. PMID 6202575.

External links

Human B3GAT2 genome location and B3GAT2 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (B3GAT2)