B3GAT3

B3GAT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FGG, 1KWS, 3CU0
Identifiers
Aliases	B3GAT3, GLCATI, glcUAT-I, JDSCD, beta-1,3-glucuronyltransferase 3
External IDs	OMIM: 606374; MGI: 1919977; HomoloGene: 56554; GeneCards: B3GAT3; OMA:B3GAT3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,622,154 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,904,600 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; granulocyte; ; right frontal lobe; ; C1 segment; ; anterior cingulate cortex; ; prefrontal cortex; ; nucleus accumbens; ; caudate nucleus; ; amygdala;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; ankle joint; ; cerebellar cortex; ; neural layer of retina; ; granulocyte; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; central gray substance of midbrain;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein phosphatase activator activity; glucuronosyltransferase activity; metal ion binding; protein binding; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; cis-Golgi network; extracellular exosome; Golgi membrane;
Biological process	positive regulation of intracellular protein transport; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; positive regulation of catalytic activity; protein glycosylation; glycosaminoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; dermatan sulfate proteoglycan biosynthetic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	26229
	72727
	ENSG00000149541
	ENSMUSG00000071649
	O94766
	P58158
	NM_001288721; NM_001288722; NM_001288723; NM_012200
	NM_024256
	NP_001275650; NP_001275651; NP_001275652; NP_036332
	NP_077218
	Wikidata
View/Edit Human	View/Edit Mouse

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.^[5]^[6]

The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071649 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K (Apr 1998). "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12): 6615–8. doi:10.1074/jbc.273.12.6615. PMID 9506957.
^ ^a ^b "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)".

External links

Human B3GAT3 genome location and B3GAT3 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O94766 (Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)) at the PDBe-KB.