ALG2

ALG2
Identifiers
Aliases	ALG2, CDGIi, NET38, hALPG2, CMS14, CMSTA3, alpha-1,3/1,6-mannosyltransferase, CDG1I, ALG2 alpha-1,3/1,6-mannosyltransferase
External IDs	OMIM: 607905; MGI: 1914731; HomoloGene: 5930; GeneCards: ALG2; OMA:ALG2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	47,474,333 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; corpus epididymis; ; caput epididymis; ; secondary oocyte; ; germinal epithelium; ; tibia; ; islet of Langerhans; ; body of pancreas; ; visceral pleura; ; parietal pleura;
	Top expressed in
	median eminence; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; arcuate nucleus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; suprachiasmatic nucleus; ; habenula; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity; transferase activity; protein N-terminus binding; protein heterodimerization activity; glycosyltransferase activity; protein binding; calcium-dependent protein binding; alpha-1,3-mannosyltransferase activity; GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity;
Cellular component	cytoplasm; integral component of membrane; nucleus; membrane; perinuclear region of cytoplasm; endoplasmic reticulum membrane; cytosol; actin cytoskeleton;
Biological process	response to calcium ion; protein glycosylation; dolichol-linked oligosaccharide biosynthetic process; mannosylation; oligosaccharide-lipid intermediate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	85365
	56737
	n/a
	ENSMUSG00000039740
	Q9H553
	Q9DBE8
	NM_033087; NM_197973
	NM_019998; NM_001355496
	NP_149078
	NP_064382; NP_001342425
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene.^[4] Mutations in the human gene are associated with congenital defects in glycosylation ^[5]^[6] The protein encoded by the ALG2 gene belongs to two classes of enzymes: GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase (EC 2.4.1.132) and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase (EC 2.4.1.257).

Function

This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).^[6]

Interactions

ALG2 has been shown to interact with ANXA7^[7] and ANXA11.^[7]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039740 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jackson BJ, Kukuruzinska MA, Robbins P (August 1993). "Biosynthesis of asparagine-linked oligosaccharides in Saccharomyces cerevisiae: the alg2 mutation". Glycobiology. 3 (4): 357–64. doi:10.1093/glycob/3.4.357. PMID 8400550.
^ Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, Kohlschütter A, von Figura K, Lehle L, Körner C (June 2003). "A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis". The Journal of Biological Chemistry. 278 (25): 22498–505. doi:10.1074/jbc.M302850200. PMID 12684507.
^ ^a ^b "Entrez Gene: ALG2 asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)".
^ ^a ^b Satoh H, Nakano Y, Shibata H, Maki M (November 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1600 (1–2): 61–7. doi:10.1016/S1570-9639(02)00445-4. PMID 12445460.