WB-4101

WB-4101
识别信息
  • 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane
CAS号613-67-2  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C19H23NO5
摩尔质量345.389
3D模型（JSmol（英语：JSmol））
  • COc1cccc(c1OCCNCC2COc3ccccc3O2)OC
  • InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3
  • Key:GYSZUJHYXCZAKI-UHFFFAOYSA-N

WB-4101，是一种化合物，可以作α1B-肾上腺素能受体的拮抗剂。1969年，WB-4101是首批为该受体开发的选择性拮抗剂之一，常用于肾上腺素受体的研究，作爲开发更具选择性药物的先导化合物。[1][2][3][4][5][6]

參見

参考文獻

  1. ^ The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes. Journal of Medicinal Chemistry. March 1969, 12 (2): 326–9. PMID 5791620. doi:10.1021/jm00302a033. 
  2. ^ Characterization of alpha 1-adrenergic receptor subtypes in rat brain: a reevaluation of [3H]WB4104 and [3H]prazosin binding. Molecular Pharmacology. April 1986, 29 (4): 321–30. PMID 3010073. 
  3. ^ Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism?. Farmaco. April 1998, 53 (4): 278–86. PMID 9658586. doi:10.1016/S0014-827X(98)00022-6. 
  4. ^ Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety. Pharmaceutica Acta Helvetiae. March 2000, 74 (2–3): 181–90. PMID 10812956. doi:10.1016/S0031-6865(99)00049-7. 
  5. ^ Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist. European Journal of Medicinal Chemistry. December 2012, 58: 184–91. PMID 23124215. doi:10.1016/j.ejmech.2012.09.049. 
  6. ^ 6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist. Journal of Medicinal Chemistry. August 2013, 56 (16): 6402–12. PMID 23902232. doi:10.1021/jm400867d.