苯呋洛尔

苯呋洛尔
臨床資料
商品名（英语：Drug nomenclature）Benfuran, Bentos, Betaclar, Glauconex
AHFS/Drugs.com国际药品名称
ATC碼
识别信息
  • (RS)-1-{7-[2-hydroxy-3-(propan-2-ylamino)propoxy]- 1-benzofuran-2-yl}ethanone
CAS号39552-01-7  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C16H21NO4
摩尔质量291.35 g·mol−1
3D模型（JSmol（英语：JSmol））
  • O=C(c2oc1c(OCC(O)CNC(C)C)cccc1c2)C
  • InChI=1S/C16H21NO4/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14/h4-7,10,13,17,19H,8-9H2,1-3H3 checkY
  • Key:ZPQPDBIHYCBNIG-UHFFFAOYSA-N checkY

苯呋洛尔（INN：Befunolol）是一种具有内在拟交感活性的β受体阻滞剂，用于治疗开角型青光眼。[1]它还充当β-肾上腺素能受体部分激动剂。[2][3]苯呋洛尔于1983年由科研药化工（Kakenyaku Kako）在日本推出，商品名为Bentos。[4]

参考资料

  1. ^ Reichl S, Müller-Goymann CC. The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride. International Journal of Pharmaceutics. January 2003, 250 (1): 191–201. PMID 12480285. doi:10.1016/S0378-5173(02)00541-0. 
  2. ^ Koike K, Takayanagi I. A beta-adrenergic partial agonist (befunolol) discriminates two different affinity sites. Japanese Journal of Pharmacology. October 1986, 42 (2): 325–8. PMID 2879061. doi:10.1254/jjp.42.325 可免费查阅. 
  3. ^ Takayanagi I, Koike K. A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs. General Pharmacology. January 1985, 16 (3): 265–7. PMID 2862092. doi:10.1016/0306-3623(85)90080-1. 
  4. ^ Pharmaceutical Manufacturing Encyclopedia 3rd revised. Norwich, N.Y.: William Andrew Publishing. January 14, 2008: 542. ISBN 978-0815515265.